Santi Aldama had the highest plus/minus in a game in 2021-22, at +52 versus the Thunder on December 2, 2021.

Interpreted as:

highest plus minus by a player in a regular-season game 2022

	NAME	+/-	DATE	TM		OPP	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Santi Aldama S. Aldama	+52	12/2/2021	MEM	vs	OKC	28	18	10	3	1	1	8	16	50.0	0	3	0.0	2	3	66.7	52.0	5	5	0	1
2	Jaren Jackson Jr. J. Jackson Jr.	+47	3/8/2022	MEM	vs	NOP	24	22	3	0	1	3	7	13	53.8	2	6	33.3	6	6	100.0	70.3	0	3	0	4
3	Obi Toppin O. Toppin	+46	4/3/2022	NYK	@	ORL	35	20	8	3	0	1	7	16	43.8	4	10	40.0	2	2	100.0	59.2	1	7	2	1
4	Terry Rozier T. Rozier	+46	2/25/2022	CHA	vs	TOR	32	23	4	9	1	1	10	16	62.5	3	7	42.9	0	0		71.9	0	4	0	3
5	De'Anthony Melton D. Melton	+46	12/2/2021	MEM	vs	OKC	22	19	6	5	0	0	8	10	80.0	3	5	60.0	0	0		95.0	1	5	1	0
6	LaMelo Ball L. Ball	+45	1/26/2022	CHA	@	IND	38	29	10	13	1	1	11	16	68.8	3	4	75.0	4	5	80.0	79.7	1	9	4	3
7	Alec Burks A. Burks	+44	4/3/2022	NYK	@	ORL	33	19	7	6	1	0	6	7	85.7	3	3	100.0	4	5	80.0	103.3	0	7	1	4
8	Reggie Jackson R. Jackson	+44	3/3/2022	LAC	vs	LAL	35	36	8	9	2	0	14	30	46.7	4	8	50.0	4	4	100.0	56.7	2	6	3	5
9	Cade Cunningham C. Cunningham	+43	3/23/2022	DET	vs	ATL	35	17	6	8	1	1	7	12	58.3	0	2	0.0	3	3	100.0	63.8	1	5	5	3
10	Bojan Bogdanović B. Bogdanović	+43	3/9/2022	UTA	vs	POR	24	27	4	2	0	0	9	14	64.3	6	9	66.7	3	4	75.0	85.7	1	3	1	0
11	Donovan Mitchell D. Mitchell	+43	3/9/2022	UTA	vs	POR	24	16	4	6	1	0	6	12	50.0	4	10	40.0	0	0		66.7	0	4	2	2
12	Royce O'Neale R. O'Neale	+43	3/9/2022	UTA	vs	POR	24	11	10	3	0	0	4	6	66.7	2	4	50.0	1	1	100.0	85.4	1	9	0	1
13	Malachi Flynn M. Flynn	+42	2/28/2022	TOR	@	BKN	34	18	4	5	2	0	7	11	63.6	3	5	60.0	1	2	50.0	75.8	1	3	0	1
14	Robert Williams III R. Williams III	+42	1/25/2022	BOS	vs	SAC	27	13	17	4	3	2	6	8	75.0	0	0		1	1	100.0	77.0	7	10	0	0
15	Tyus Jones T. Jones	+42	12/2/2021	MEM	vs	OKC	21	10	6	9	2	0	4	7	57.1	1	2	50.0	1	1	100.0	67.2	1	5	1	0
16	Jaren Jackson Jr. J. Jackson Jr.	+42	12/2/2021	MEM	vs	OKC	20	27	3	1	2	2	9	11	81.8	6	7	85.7	3	3	100.0	109.6	0	3	1	0
17	Luka Dončić L. Dončić	+41	4/8/2022	DAL	vs	POR	30	39	11	7	0	1	12	21	57.1	7	14	50.0	8	11	72.7	75.5	0	11	5	0
18	Kelly Oubre Jr. K. Oubre Jr.	+41	4/7/2022	CHA	vs	ORL	24	16	6	1	0	0	5	9	55.6	2	5	40.0	4	6	66.7	68.7	1	5	0	3
19	Amir Coffey A. Coffey	+41	4/1/2022	LAC	@	MIL	43	32	6	7	4	0	10	16	62.5	5	9	55.6	7	7	100.0	83.9	0	6	0	2
20	Derrick White D. White	+41	2/15/2022	BOS	@	PHI	28	11	1	2	1	1	4	9	44.4	0	3	0.0	3	3	100.0	53.3	1	0	1	4
21	Amir Coffey A. Coffey	+40	4/10/2022	LAC	vs	OKC	43	35	13	5	0	1	13	22	59.1	7	10	70.0	2	2	100.0	76.5	2	11	2	1
22	Desmond Bane D. Bane	+40	3/24/2022	MEM	vs	IND	24	30	5	5	0	1	12	15	80.0	5	7	71.4	1	1	100.0	97.2	1	4	1	1
23	Jayson Tatum J. Tatum	+40	3/18/2022	BOS	@	SAC	34	32	5	4	0	0	12	16	75.0	7	10	70.0	1	1	100.0	97.3	0	5	2	1
24	Devin Vassell D. Vassell	+40	2/11/2022	SAS	@	ATL	28	20	5	3	1	0	9	13	69.2	2	2	100.0	0	0		76.9	1	4	0	1
25	Marcus Smart M. Smart	+40	2/8/2022	BOS	@	BKN	28	22	1	3	1	1	8	16	50.0	6	13	46.2	0	0		68.8	0	1	1	2