I don't have anything for this season, but the Los Angeles Lakers had their highest point differential in a game in 2024-25 against the Wizards on January 30, with a 38 point differential.

Interpreted as:

lakers best win margins in a regular-season game this season

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Lakers	38	1/30/2025	LAL	@	WAS	W 134-96	240	134	48	31	9	6	49	90	54.4	15	32	46.9	21	22	95.5	67.2	9	39	11	24
2	Lakers	31	4/11/2025	LAL	vs	HOU	W 140-109	240	140	42	28	11	1	53	87	60.9	19	37	51.4	15	25	60.0	71.4	4	38	12	15
3	Lakers	27	4/6/2025	LAL	@	OKC	W 126-99	240	126	43	25	6	2	46	84	54.8	22	40	55.0	12	17	70.6	68.9	8	35	15	15
4	Lakers	25	2/4/2025	LAL	@	LAC	W 122-97	240	122	50	33	7	3	45	81	55.6	18	37	48.6	14	23	60.9	66.9	10	40	14	15
5	Lakers	23	2/22/2025	LAL	@	DEN	W 123-100	240	123	39	27	15	9	43	86	50.0	16	41	39.0	21	25	84.0	63.4	9	30	8	20
6	Lakers	23	1/21/2025	LAL	vs	WAS	W 111-88	240	111	50	30	6	10	43	90	47.8	11	34	32.4	14	18	77.8	56.7	7	43	10	11
7	Lakers	21	3/4/2025	LAL	vs	NOP	W 136-115	240	136	51	32	7	5	48	90	53.3	19	52	36.5	21	27	77.8	66.7	17	34	14	12
8	Lakers	21	1/23/2025	LAL	vs	BOS	W 117-96	240	117	53	27	4	3	42	89	47.2	15	35	42.9	18	20	90.0	59.8	10	43	6	14
9	Lakers	20	11/10/2024	LAL	vs	TOR	W 123-103	240	123	33	30	9	4	44	86	51.2	12	37	32.4	23	28	82.1	62.6	10	23	5	15
10	Lakers	19	2/10/2025	LAL	vs	UTA	W 132-113	240	132	44	28	11	2	50	92	54.3	15	42	35.7	17	18	94.4	66.1	10	34	11	22
11	Lakers	18	11/27/2024	LAL	@	SAS	W 119-101	240	119	46	31	8	3	48	90	53.3	13	34	38.2	10	10	100.0	63.0	11	35	13	15
12	Lakers	17	1/3/2025	LAL	vs	ATL	W 119-102	240	119	56	28	4	6	43	88	48.9	13	30	43.3	20	25	80.0	60.1	17	39	18	21
13	Lakers	16	4/4/2025	LAL	vs	NOP	W 124-108	240	124	36	26	7	2	41	79	51.9	16	41	39.0	26	28	92.9	67.9	8	28	12	18
14	Lakers	16	3/17/2025	LAL	vs	SAS	W 125-109	240	125	42	34	13	4	44	90	48.9	19	48	39.6	18	24	75.0	62.2	8	34	9	10
15	Lakers	16	2/1/2025	LAL	@	NYK	W 128-112	240	128	37	26	9	4	47	81	58.0	19	40	47.5	15	18	83.3	72.0	3	34	15	22
16	Lakers	15	4/9/2025	LAL	@	DAL	W 112-97	240	112	39	22	14	0	42	90	46.7	12	36	33.3	16	21	76.2	56.4	15	24	9	16
17	Lakers	13	12/19/2024	LAL	@	SAC	W 113-100	240	113	53	22	8	10	38	94	40.4	12	33	36.4	25	30	83.3	52.7	14	39	10	16
18	Lakers	12	3/19/2025	LAL	vs	DEN	W 120-108	240	120	38	25	13	3	42	83	50.6	16	38	42.1	20	28	71.4	62.9	8	30	13	17
19	Lakers	11	3/16/2025	LAL	vs	PHX	W 107-96	240	107	40	22	7	5	35	81	43.2	14	39	35.9	23	32	71.9	56.3	7	33	8	20
20	Lakers	10	1/25/2025	LAL	@	GSW	W 118-108	240	118	42	29	8	2	47	86	54.7	10	29	34.5	14	17	82.4	63.1	10	32	12	13
21	Lakers	10	12/28/2024	LAL	vs	SAC	W 132-122	240	132	33	33	4	3	46	77	59.7	14	26	53.8	26	33	78.8	72.1	4	29	11	13
22	Lakers	10	11/8/2024	LAL	vs	PHI	W 116-106	240	116	45	28	1	13	44	85	51.8	16	35	45.7	12	14	85.7	63.6	5	40	11	17
23	Lakers	9	2/27/2025	LAL	vs	MIN	W 111-102	240	111	52	21	7	2	34	82	41.5	11	41	26.8	32	46	69.6	54.3	16	36	12	18
24	Lakers	9	1/15/2025	LAL	vs	MIA	W 117-108	240	117	34	33	12	4	47	90	52.2	13	34	38.2	10	14	71.4	60.8	6	28	6	12
25	Lakers	9	12/8/2024	LAL	vs	POR	W 107-98	240	107	40	25	14	7	38	83	45.8	13	34	38.2	18	21	85.7	58.0	8	32	11	20