LeBron James played his most minutes in a game against the Grizzlies on November 29, 2003, with 55 minutes on the court.

Interpreted as:

most minutes in a regular-season game in james career

	NAME	MIN	DATE	TM		OPP	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	LeBron James L. James	55	11/29/2003	CLE	vs	MEM	33	16	7	1	1	14	28	50.0	3	6	50.0	2	3	66.7	56.3	2	14	8	1	-10
2	LeBron James L. James	54	2/15/2006	CLE	@	BOS	43	12	11	2	4	16	32	50.0	0	5	0.0	11	15	73.3	55.7	1	11	2	5	+5
3	LeBron James L. James	53	1/24/2007	CLE	vs	PHI	39	10	5	1	0	14	26	53.8	3	8	37.5	8	13	61.5	61.5	2	8	4	2	-8
4	LeBron James L. James	53	3/31/2005	CLE	@	CHI	26	6	7	4	2	10	28	35.7	1	4	25.0	5	11	45.5	39.6	4	2	3	5	-12
5	LeBron James L. James	53	3/28/2005	CLE	@	NOH	44	6	3	4	0	16	29	55.2	3	10	30.0	9	11	81.8	65.0	2	4	10	3	+1
6	James Worthy J. Worthy	53	11/1/1991	LAL	@	HOU	37	4	7	2	1	14	28	50.0	3	3	100.0	6	6	100.0	60.4	2	2	7	2
7	LeBron James L. James	52	1/27/2013	MIA	@	BOS	34	16	7	3	1	14	31	45.2	3	6	50.0	3	5	60.0	51.2	4	12	3	3	-2
8	LeBron James L. James	52	4/2/2017	CLE	vs	IND	41	14	11	2	1	16	29	55.2	3	10	30.0	6	12	50.0	59.8	4	10	1	4	-1
9	LeBron James L. James	51	3/7/2007	CLE	@	DET	41	7	8	3	1	17	31	54.8	1	3	33.3	6	8	75.0	59.4	2	5	4	4	+8
10	James Harden J. Harden	51	1/20/2021	BKN	@	CLE	21	10	12	2	0	6	14	42.9	3	6	50.0	6	6	100.0	63.1	1	9	5	5	-5
11	LeBron James L. James	50	12/17/2007	CLE	vs	MIL	31	8	5	1	0	10	25	40.0	0	5	0.0	11	13	84.6	50.5	1	7	2	3	+6
12	LeBron James L. James	50	3/22/2006	CLE	vs	CHA	37	11	12	0	1	10	21	47.6	1	5	20.0	16	23	69.6	59.4	0	11	5	4	+5
13	LeBron James L. James	50	11/3/2004	CLE	vs	IND	28	5	8	1	3	8	19	42.1	2	5	40.0	10	12	83.3	57.7	1	4	6	2	-10
14	James Worthy J. Worthy	50	11/15/1988	LAL	@	DEN	33	9	7	1	3	12	24	50.0	0	0		9	10	90.0	58.1	2	7	2	3
15	LeBron James L. James	50	11/30/2005	CLE	vs	LAC	28	7	9	1	1	7	20	35.0	0	3	0.0	14	17	82.4	50.9	0	7	6	1	+6
16	LeBron James L. James	50	11/26/2021	LAL	vs	SAC	30	7	11	1	0	10	25	40.0	2	13	15.4	8	11	72.7	50.3	1	6	7	4	-7
17	LeBron James L. James	50	1/11/2008	CLE	vs	CHA	31	19	8	4	3	10	20	50.0	2	7	28.6	9	15	60.0	58.3	5	14	8	3	-2
18	LeBron James L. James	49	1/10/2014	MIA	@	BKN	36	7	5	0	0	12	21	57.1	2	5	40.0	10	12	83.3	68.5	3	4	4	6	-1
19	James Harden J. Harden	49	2/13/2025	LAC	@	UTA	32	10	7	3	2	8	19	42.1	5	13	38.5	11	15	73.3	62.5	1	9	3	4	+11
20	LeBron James L. James	49	1/11/2005	CLE	vs	CHA	29	8	9	2	1	11	24	45.8	2	5	40.0	5	7	71.4	53.5	1	7	8	1	+7
21	LeBron James L. James	49	2/27/2004	CLE	@	ORL	30	11	3	3	1	11	19	57.9	1	1	100.0	7	8	87.5	66.6	1	10	5	1	+7
22	James Worthy J. Worthy	49	11/5/1991	LAL	vs	LAC	22	7	7	3	2	10	21	47.6	0	0		2	2	100.0	50.3	0	7	2	1
23	James Worthy J. Worthy	49	2/24/1991	LAL	@	DET	29	5	2	2	0	14	27	51.9	0	1	0.0	1	6	16.7	48.9	1	4	0	3
24	James Worthy J. Worthy	49	3/8/1986	LAL	vs	SAC	32	7	3	1	2	12	20	60.0	0	0		8	12	66.7	63.3	1	6	0	2
25	LeBron James L. James	49	3/26/2006	CLE	@	HOU	36	6	5	2	0	14	34	41.2	0	4	0.0	8	11	72.7	46.3	3	3	2	2	+4