Kobe Bryant has the most points in a game versus the Grizzlies, with 60 points on March 22, 2007.

Interpreted as:

most points by a player in a regular-season game vs vancouver

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Kobe Bryant K. Bryant	60	3/22/2007	LAL	@	MEM	45	5	4	0	0	20	37	54.1	3	7	42.9	17	18	94.4	66.8	2	3	2	4	+2
2	James Harden J. Harden	57	3/20/2019	HOU	@	MEM	46	7	8	2	2	18	39	46.2	9	17	52.9	12	12	100.0	64.4	1	6	3	3	+11
3	James Harden J. Harden	57	1/14/2019	HOU	vs	MEM	34	9	2	2	1	17	33	51.5	6	15	40.0	17	18	94.4	69.6	2	7	5	4	+25
4	Kobe Bryant K. Bryant	56	1/14/2002	LAL	vs	MEM	34	5	4	1	0	21	34	61.8	3	6	50.0	11	12	91.7	71.3	3	2	0	1	+40
5	Kobe Bryant K. Bryant	53	3/28/2008	LAL	vs	MEM	42	10	1	3	0	19	37	51.4	9	17	52.9	6	7	85.7	66.1	2	8	1	4	+1
6	Stephen Curry S. Curry	52	4/1/2025	GSW	@	MEM	37	10	8	5	1	16	31	51.6	12	20	60.0	8	8	100.0	75.3	1	9	2	2	+17
7	LeBron James L. James	51	1/15/2008	CLE	@	MEM	47	8	9	3	1	18	28	64.3	6	12	50.0	9	16	56.3	72.8	3	5	4	1	+10
8	Jamal Mashburn J. Mashburn	50	2/21/2003	NOH	vs	MEM	46	5	5	1	0	17	33	51.5	4	7	57.1	12	12	100.0	65.3	2	3	3	2	+6
9	Devin Booker D. Booker	48	3/30/2019	PHX	vs	MEM	43	3	11	0	0	19	29	65.5	3	6	50.0	7	8	87.5	73.8	1	2	6	3	+1
10	Kevin Martin K. Martin	48	11/2/2009	SAC	vs	MEM	52	5	4	4	1	14	27	51.9	7	10	70.0	13	18	72.2	68.7	1	4	3	2	+10
11	Nikola Jokić N. Jokić	47	4/19/2021	DEN	vs	MEM	45	15	8	0	1	20	31	64.5	2	6	33.3	5	6	83.3	69.9	7	8	7	3	+3
12	John Wall J. Wall	47	3/25/2013	WAS	vs	MEM	45	7	8	1	1	13	22	59.1	2	4	50.0	19	24	79.2	72.2	0	7	2	2	+26
13	Stephen Curry S. Curry	46	12/23/2021	GSW	vs	MEM	37	4	4	2	0	13	22	59.1	8	14	57.1	12	12	100.0	84.3	0	4	3	1	+15
14	Stephen Curry S. Curry	46	5/16/2021	GSW	vs	MEM	40	7	9	1	1	16	36	44.4	9	22	40.9	5	6	83.3	59.5	1	6	7	2	+14
15	Kemba Walker K. Walker	46	3/22/2018	CHA	vs	MEM	28	3	4	1	0	13	18	72.2	10	14	71.4	10	10	100.0	102.7	0	3	2	1	+47
16	Stephen Curry S. Curry	46	4/13/2016	GSW	vs	MEM	30	4	6	2	0	15	24	62.5	10	19	52.6	6	6	100.0	86.3	1	3	2	2	+19
17	Antonio McDyess A. McDyess	46	2/28/1999	DEN	vs	VAN	41	19	1	1	4	16	25	64.0	0	0		14	18	77.8	69.9	8	11	3	4	+2
18	Russell Westbrook R. Westbrook	45	4/5/2017	OKC	@	MEM	38	9	10	4	0	14	25	56.0	8	13	61.5	9	12	75.0	74.3	0	9	7	4	+3
19	Kobe Bryant K. Bryant	45	12/28/2005	LAL	vs	MEM	47	7	4	2	1	13	37	35.1	4	8	50.0	15	19	78.9	49.6	2	5	2	5	-6
20	Kobe Bryant K. Bryant	45	11/29/2002	LAL	@	MEM	48	6	5	2	0	18	35	51.4	2	4	50.0	7	9	77.8	57.8	1	5	5	0	+8
21	Anthony Edwards A. Edwards	44	4/10/2025	MIN	@	MEM	38	5	3	1	1	13	19	68.4	7	11	63.6	11	13	84.6	89.0	1	4	5	3	+15
22	James Harden J. Harden	44	11/4/2019	HOU	@	MEM	37	10	6	2	1	12	28	42.9	7	16	43.8	13	18	72.2	61.2	4	6	7	2	+11
23	Isaiah Thomas I. Thomas	44	12/20/2016	BOS	@	MEM	38	3	6	2	1	10	16	62.5	7	10	70.0	17	17	100.0	93.7	0	3	1	1	+9
24	Kobe Bryant K. Bryant	44	2/1/2010	LAL	@	MEM	40	3	3	0	0	16	28	57.1	4	7	57.1	8	13	61.5	65.2	0	3	3	1	+5
25	Elton Brand E. Brand	44	2/10/2006	LAC	vs	MEM	45	9	2	2	2	17	26	65.4	0	0		10	10	100.0	72.4	2	7	4	4	-2