The New York Knicks had their lowest point differential in a game against the Syracuse Nationals on December 25, 1960, with a -62 point differential.

Interpreted as:

What is the worst knicks loss in a regular-season game ever?

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Knicks	-62	12/25/1960	NYK	@	SYR	L 100-162	240	100					34						32	42	76.2					25
2	Knicks	-50	1/24/2010	NYK	vs	DAL	L 78-128	240	78	46	14	4	2	29	86	33.7	4	25	16.0	16	21	76.2	40.9	22	24	16	15
3	Knicks	-47	3/18/1972	NYK	@	POR	L 86-133	240	86	38	21			35	94	37.2				16	25	64.0	41.0				22
4	Knicks	-45	11/29/2007	NYK	@	BOS	L 59-104	240	59	35	12	3	6	23	76	30.3	2	10	20.0	11	17	64.7	35.3	7	28	14	22
5	Knicks	-45	2/20/1980	NYK	@	IND	L 86-131	240	86	50	21	10	3	37	95	38.9	0	4	0.0	12	26	46.2	40.4			33	25
6	Knicks	-44	12/2/2019	NYK	@	MIL	L 88-132	240	88	42	13	4	7	28	91	30.8	10	39	25.6	22	33	66.7	41.7	14	28	10	21
7	Knicks	-44	1/31/1954	NYK	@	SYR	L 70-114	240	70	31	18			25	79	31.6				20	32	62.5	37.6				27
8	Knicks	-43	1/21/2002	NYK	vs	CHA	L 68-111	240	68	37	15	5	3	25	83	30.1	3	15	20.0	15	18	83.3	37.4	14	23	16	24
9	Knicks	-43	3/24/1972	NYK	@	MIL	L 88-131	240	88	34	17			36	102	35.3				16	20	80.0	39.7				17
10	Knicks	-42	11/28/1962	NYK	@	DET	L 101-143	240	101					39						23	35	65.7					19
11	Knicks	-41	12/8/2013	NYK	vs	BOS	L 73-114	240	73	26	13	10	3	25	73	34.2	6	16	37.5	17	23	73.9	43.9	4	22	14	18
12	Knicks	-41	12/15/1962	NYK	@	CHI	L 101-142	240	101					41						19	31	61.3					24
13	Knicks	-40	2/20/2008	NYK	@	PHI	L 84-124	240	84	31	25	5	2	34	74	45.9	5	22	22.7	11	15	73.3	52.1	9	22	23	18
14	Knicks	-40	12/10/1961	NYK	@	CIN	L 94-134	240	94	59				38	116	32.8				18	28	64.3	36.6				11
15	Knicks	-39	4/10/1987	NYK	vs	MIL	L 93-132	240	93	41	18	7	5	32	78	41.0	2	10	20.0	27	44	61.4	47.8	13	28	27	21
16	Knicks	-39	3/24/1987	NYK	@	MIL	L 96-135	240	96	55	14	7	2	37	98	37.8	3	8	37.5	19	37	51.4	42.0	25	30	16	29
17	Knicks	-38	3/3/2015	NYK	vs	SAC	L 86-124	240	86	38	16	8	9	30	82	36.6	4	22	18.2	22	30	73.3	45.2	9	29	15	27
18	Knicks	-38	4/12/1986	NYK	@	MIL	L 78-116	240	78	27	19	13	3	32	81	39.5	1	3	33.3	13	19	68.4	43.6	11	16	21	29
19	Knicks	-37	2/21/2025	NYK	@	CLE	L 105-142	240	105	32	25	8	3	42	89	47.2	10	28	35.7	11	18	61.1	54.2	9	23	16	12
20	Knicks	-37	12/5/2019	NYK	vs	DEN	L 92-129	240	92	33	23	9	7	34	83	41.0	9	34	26.5	15	23	65.2	49.4	5	28	14	16
21	Knicks	-37	4/3/1987	NYK	@	ATL	L 89-126	240	89	40	20	8	3	35	93	37.6	1	7	14.3	18	24	75.0	43.0	20	20	18	24
22	Knicks	-37	10/21/1961	NYK	@	PHI	L 95-132	240	95	62	21			41	115	35.7				13	22	59.1	38.1				23
23	Knicks	-37	3/1/1961	NYK		LAL	L 107-144	240	107					38						31	40	77.5					24
24	Knicks	-36	3/18/2019	NYK	@	TOR	L 92-128	240	92	36	16	8	4	28	85	32.9	8	35	22.9	28	32	87.5	46.4	7	29	13	18
25	Knicks	-36	3/16/2016	NYK	@	GSW	L 85-121	240	85	38	29	7	3	36	91	39.6	7	19	36.8	6	10	60.0	44.5	11	27	9	11