I didn't find anything for this season, but Pascal Siakam had the highest plus/minus versus the 76ers in 2024-25, at +75.

Interpreted as:

best +/- by a player this season vs. 76ers

	NAME	+/-	SEASON	TM	GP	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	PTS	REB	AST	STL	BLK	TOV	PF
1	Pascal Siakam P. Siakam	+75	2024-25	IND	4	33.5	22.0	7.0	4.5	0.5	1.5	8.5	13.5	63.0	1.3	3.0	41.7	3.8	6.0	62.5	68.2	1.8	5.3	1.3	134	88	28	18	2	6	5	8
2	Caris LeVert C. LeVert	+65	2024-25	TOT	4	26.4	14.3	2.8	4.3	1.3	0.8	5.5	11.3	48.9	2.0	5.0	40.0	1.3	2.0	62.5	58.7	0.8	2.0	1.3	106	57	11	17	5	3	5	8
3	Zach Collins Z. Collins	+59	2024-25	CHI	2	21.4	16.0	4.5	1.5	0.5	0.5	5.0	8.5	58.8	1.0	2.0	50.0	5.0	5.0	100.0	74.8	2.0	2.5	0.5	43	32	9	3	1	1	1	4
4	Andrew Nembhard A. Nembhard	+59	2024-25	IND	4	31.5	6.8	2.3	6.3	0.0	0.0	2.3	7.3	31.0	0.8	3.5	21.4	1.5	2.5	60.0	40.4	0.0	2.3	0.8	126	27	9	25	0	0	3	14
5	Matas Buzelis M. Buzelis	+58	2024-25	CHI	4	21.4	8.8	3.0	1.5	0.3	0.5	3.3	7.3	44.8	0.8	3.3	23.1	1.5	1.8	85.7	54.6	0.8	2.3	1.0	86	35	12	6	1	2	4	4
6	Kris Dunn K. Dunn	+55	2024-25	LAC	2	20.4	6.5	2.0	3.0	2.0	0.0	3.0	4.0	75.0	0.5	1.0	50.0	0.0	0.0		81.3	1.0	1.0	1.5	41	13	4	6	4	0	3	6
7	Giannis Antetokounmpo G. Antetokounmpo	+55	2024-25	MIL	3	35.4	31.3	15.3	11.0	0.7	0.3	11.0	15.7	70.2	0.3	0.3	100.0	9.0	13.7	65.9	72.3	2.0	13.3	1.7	106	94	46	33	2	1	5	6
8	Luke Kornet L. Kornet	+54	2024-25	BOS	4	20.8	5.8	6.5	2.5	0.3	2.0	2.8	3.3	84.6	0.0	0.0		0.3	0.8	33.3	80.3	3.5	3.0	0.3	83	23	26	10	1	8	1	7
9	AJ Green	+52	2024-25	MIL	3	16.0	7.7	2.0	1.0	0.7	0.0	2.3	4.0	58.3	2.0	3.0	66.7	1.0	1.0	100.0	86.3	0.3	1.7	0.3	48	23	6	3	2	0	1	2
10	Davion Mitchell D. Mitchell	+50	2024-25	TOT	3	29.0	8.7	2.7	6.7	1.0	0.3	3.3	8.3	40.0	1.0	3.3	30.0	1.0	1.3	75.0	48.6	0.3	2.3	2.3	87	26	8	20	3	1	7	13
11	Ivica Zubac I. Zubac	+48	2024-25	LAC	2	29.3	15.5	10.5	3.5	0.5	0.5	7.5	9.5	78.9	0.0	0.0		0.5	1.0	50.0	78.0	2.5	8.0	1.5	59	31	21	7	1	1	3	1
12	Nickeil Alexander-Walker N. Alexander-Walker	+46	2024-25	MIN	2	27.2	13.5	2.5	4.0	1.0	0.0	5.0	8.0	62.5	1.5	4.0	37.5	2.0	2.5	80.0	74.2	0.5	2.0	0.0	54	27	5	8	2	0	0	1
13	Jayson Tatum J. Tatum	+45	2024-25	BOS	4	38.0	29.3	10.0	6.8	1.5	0.5	10.8	19.0	56.6	4.0	8.5	47.1	3.8	4.3	88.2	70.1	0.8	9.3	3.3	152	117	40	27	6	2	13	8
14	Myles Turner M. Turner	+45	2024-25	IND	4	29.5	14.3	7.0	1.8	1.0	1.0	5.3	11.8	44.7	1.5	4.0	37.5	2.3	3.5	64.3	53.6	1.8	5.3	2.3	118	57	28	7	4	4	9	15
15	Stephen Curry S. Curry	+44	2024-25	GSW	2	33.1	29.5	5.5	11.5	1.0	0.0	10.5	16.5	63.6	6.5	10.0	65.0	2.0	2.0	100.0	84.9	1.0	4.5	2.5	66	59	11	23	2	0	5	3
16	Amir Coffey A. Coffey	+44	2024-25	LAC	2	24.9	9.0	3.0	1.0	0.0	0.0	3.0	6.5	46.2	2.0	4.0	50.0	1.0	1.5	66.7	62.8	1.0	2.0	0.0	50	18	6	2	0	0	0	0
17	Mouhamed Gueye M. Gueye	+43	2024-25	ATL	3	22.6	10.0	8.7	2.0	1.3	1.0	3.7	6.7	55.0	1.0	2.3	42.9	1.7	1.7	100.0	67.6	4.3	4.3	0.7	68	30	26	6	4	3	2	3
18	James Harden J. Harden	+43	2024-25	LAC	2	30.5	20.5	3.0	7.0	2.0	0.5	4.5	12.5	36.0	2.0	6.5	30.8	9.5	10.5	90.5	59.9	0.0	3.0	5.0	61	41	6	14	4	1	10	2
19	Derrick Jones Jr. D. Jones Jr.	+42	2024-25	LAC	2	24.2	16.0	3.5	2.0	1.5	0.0	6.0	8.0	75.0	1.0	1.5	66.7	3.0	3.5	85.7	83.9	1.0	2.5	0.0	48	32	7	4	3	0	0	4
20	Jeremiah Robinson-Earl J. Robinson-Earl	+41	2024-25	NOP	2	21.1	3.5	6.0	3.0	0.5	0.0	1.5	3.0	50.0	0.5	1.5	33.3	0.0	0.0		58.3	1.5	4.5	0.0	42	7	12	6	1	0	0	3
21	Josh Hart J. Hart	+40	2024-25	NYK	4	39.4	10.0	12.5	8.0	2.0	0.5	4.3	7.3	58.6	0.3	1.5	16.7	1.3	2.3	55.6	60.7	2.3	10.3	3.8	157	40	50	32	8	2	15	11
22	Isaiah Joe I. Joe	+39	2024-25	OKC	2	25.1	15.5	2.0	3.0	0.0	0.0	5.5	10.5	52.4	3.5	7.5	46.7	1.0	1.0	100.0	70.8	0.0	2.0	2.0	50	31	4	6	0	0	4	1
23	Bam Adebayo B. Adebayo	+39	2024-25	MIA	3	31.1	13.0	11.0	4.0	0.7	0.3	5.0	12.7	39.5	1.3	2.3	57.1	1.7	2.3	71.4	47.5	3.3	7.7	3.7	93	39	33	12	2	1	11	8
24	Mike Conley M. Conley	+37	2024-25	MIN	2	24.7	10.0	5.5	5.0	0.0	0.0	3.5	6.5	53.8	2.5	4.5	55.6	0.5	0.5	100.0	74.4	0.5	5.0	2.0	49	20	11	10	0	0	4	2
25	Al Horford A. Horford	+37	2024-25	BOS	3	21.0	10.7	3.3	1.0	0.3	0.3	3.7	8.0	45.8	2.7	5.7	47.1	0.7	0.7	100.0	64.3	0.3	3.0	0.0	63	32	10	3	1	1	0	5