Tayshaun Prince had the highest plus/minus in 2005-06, at +646.

Interpreted as:

best total plus minus by a player 2005-2006

	NAME	+/-	SEASON	TM	GP	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	MPG	PPG	RPG	APG	SPG	BPG	TPG
1	Tayshaun Prince T. Prince	+646	2005-06	DET	82	2,898	1,156	346	186	62	39	455	999	45.5	64	183	35.0	182	238	76.5	52.4	104	242	91	96	35.3	14.1	4.2	2.3	0.8	0.5	1.1
2	Rasheed Wallace R. Wallace	+614	2005-06	DET	80	2,780	1,209	547	182	82	130	459	1,067	43.0	155	434	35.7	136	183	74.3	52.7	90	457	85	232	34.8	15.1	6.8	2.3	1.0	1.6	1.1
3	Ben Wallace B. Wallace	+598	2005-06	DET	82	2,890	597	923	158	146	181	237	465	51.0	0	4	0.0	123	296	41.6	50.1	301	622	88	164	35.2	7.3	11.3	1.9	1.8	2.2	1.1
4	Chauncey Billups C. Billups	+588	2005-06	DET	81	2,925	1,495	252	699	71	8	423	1,012	41.8	184	425	43.3	465	520	89.4	60.2	41	211	170	160	36.1	18.5	3.1	8.6	0.9	0.1	2.1
5	Tim Duncan T. Duncan	+519	2005-06	SAS	80	2,784	1,485	881	253	70	162	574	1,185	48.4	2	5	40.0	335	533	62.9	52.3	231	650	198	219	34.8	18.6	11.0	3.2	0.9	2.0	2.5
6	Richard Hamilton R. Hamilton	+519	2005-06	DET	80	2,825	1,609	256	275	52	16	649	1,322	49.1	55	120	45.8	256	303	84.5	55.3	84	172	173	207	35.3	20.1	3.2	3.4	0.7	0.2	2.2
7	Tony Parker T. Parker	+510	2005-06	SAS	80	2,715	1,510	261	460	83	4	623	1,136	54.8	11	36	30.6	253	358	70.7	58.4	38	223	249	161	33.9	18.9	3.3	5.8	1.0	0.1	3.1
8	Dirk Nowitzki D. Nowitzki	+509	2005-06	DAL	81	3,089	2,151	728	226	58	83	751	1,564	48.0	110	271	40.6	539	598	90.1	58.9	115	613	156	164	38.1	26.6	9.0	2.8	0.7	1.0	1.9
9	Boris Diaw B. Diaw	+490	2005-06	PHX	81	2,874	1,080	558	503	58	85	449	853	52.6	8	30	26.7	174	238	73.1	56.4	159	399	189	260	35.5	13.3	6.9	6.2	0.7	1.0	2.3
10	Dwyane Wade D. Wade	+485	2005-06	MIA	75	2,892	2,040	430	503	146	58	699	1,413	49.5	13	76	17.1	629	803	78.3	57.7	107	323	268	217	38.6	27.2	5.7	6.7	1.9	0.8	3.6
11	Jason Terry J. Terry	+476	2005-06	DAL	80	2,798	1,371	158	306	100	27	516	1,099	47.0	171	416	41.1	168	210	80.0	57.5	31	127	135	196	35.0	17.1	2.0	3.8	1.3	0.3	1.7
12	Steve Nash S. Nash	+472	2005-06	PHX	79	2,796	1,489	333	826	61	12	541	1,056	51.2	150	342	43.9	257	279	92.1	63.2	47	286	276	120	35.4	18.8	4.2	10.5	0.8	0.2	3.5
13	Shawn Marion S. Marion	+412	2005-06	PHX	81	3,263	1,769	959	143	160	137	716	1,365	52.5	96	290	33.1	241	298	80.9	59.1	249	710	125	223	40.3	21.8	11.8	1.8	2.0	1.7	1.5
14	Manu Ginobili M. Ginobili	+408	2005-06	SAS	65	1,813	981	230	235	101	26	309	669	46.2	83	217	38.2	280	360	77.8	59.3	42	188	121	156	27.9	15.1	3.5	3.6	1.6	0.4	1.9
15	Raja Bell R. Bell	+369	2005-06	PHX	79	2,959	1,162	253	207	76	22	425	930	45.7	197	446	44.2	115	146	78.8	58.4	44	209	89	248	37.5	14.7	3.2	2.6	1.0	0.3	1.1
16	Bruce Bowen B. Bowen	+360	2005-06	SAS	82	2,755	619	320	126	79	30	232	536	43.3	104	245	42.4	51	84	60.7	54.0	35	285	67	191	33.6	7.5	3.9	1.5	1.0	0.4	0.8
17	Shane Battier S. Battier	+357	2005-06	MEM	81	2,839	818	429	136	92	114	303	621	48.8	65	165	39.4	147	208	70.7	57.4	164	265	90	223	35.0	10.1	5.3	1.7	1.1	1.4	1.1
18	Metta Sandiford-Artest M. Sandiford-Artest	+347	2005-06	TOT	56	2,207	984	286	203	122	41	350	867	40.4	78	253	30.8	206	305	67.5	49.1	75	211	131	164	39.4	17.6	5.1	3.6	2.2	0.7	2.3
19	Vince Carter V. Carter	+330	2005-06	NJN	79	2,906	1,911	462	338	94	53	653	1,518	43.0	125	367	34.1	480	601	79.9	53.6	135	327	213	235	36.8	24.2	5.8	4.3	1.2	0.7	2.7
20	Kobe Bryant K. Bryant	+320	2005-06	LAL	80	3,277	2,832	425	360	147	30	978	2,173	45.0	180	518	34.7	696	819	85.0	55.9	71	354	250	233	41.0	35.4	5.3	4.5	1.8	0.4	3.1
21	Eddie Jones E. Jones	+318	2005-06	MEM	75	2,437	885	279	177	131	27	292	722	40.4	133	374	35.6	168	215	78.1	54.2	35	244	93	201	32.5	11.8	3.7	2.4	1.7	0.4	1.2
22	Josh Howard J. Howard	+314	2005-06	DAL	59	1,915	923	371	111	68	26	350	743	47.1	27	63	42.9	196	267	73.4	53.6	123	248	79	167	32.5	15.6	6.3	1.9	1.2	0.4	1.3
23	Pau Gasol P. Gasol	+301	2005-06	MEM	80	3,135	1,628	713	371	46	153	600	1,194	50.3	3	12	25.0	425	617	68.9	55.5	191	522	235	184	39.2	20.4	8.9	4.6	0.6	1.9	2.9
24	LeBron James L. James	+275	2005-06	CLE	79	3,361	2,478	556	521	123	66	875	1,823	48.0	127	379	33.5	601	814	73.8	56.8	75	481	260	181	42.5	31.4	7.0	6.6	1.6	0.8	3.3
25	Udonis Haslem U. Haslem	+270	2005-06	MIA	81	2,491	757	634	95	50	17	300	591	50.8	0	2	0.0	157	199	78.9	55.8	167	467	80	216	30.8	9.3	7.8	1.2	0.6	0.2	1.0