Between the 2003-04 and 2021-22 seasons, James Harden had the most games with 40+ points, with 101 games.

Interpreted as:

most 40 or more point regular-season games by a player 2003-04 to 2021-22

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	James Harden J. Harden	101	4,584	39.6	45.4	7.5	8.2	2.2	0.7	13.3	26.4	50.4	5.6	12.8	43.6	13.2	15.0	88.1	68.8	1.2	6.3	4.9	4,003	757	824	220	75	497	308	+967
2	Kobe Bryant K. Bryant	95	4,292	42.6	45.2	6.2	4.2	1.7	0.5	15.2	29.7	51.2	3.0	6.9	43.2	11.7	13.7	85.2	63.1	1.2	5.0	3.2	4,047	593	398	165	48	301	267	+524
3	LeBron James L. James	69	3,090	42.2	44.8	8.6	7.1	1.8	1.0	15.8	26.9	58.7	3.6	7.2	49.6	9.6	12.2	78.7	69.3	1.6	7.0	3.7	2,908	591	488	127	66	254	137	+583
4	Kevin Durant K. Durant	62	2,717	42.0	43.8	8.4	4.5	1.2	1.2	14.6	25.9	56.5	3.8	7.9	48.6	10.8	12.1	89.1	70.2	0.9	7.5	3.7	2,602	523	280	73	72	227	147	+385
5	Stephen Curry S. Curry	56	2,527	36.5	45.1	5.4	5.8	1.4	0.3	14.6	25.1	58.2	8.6	15.1	57.1	7.2	7.8	93.1	79.0	0.7	4.7	3.5	2,046	302	326	81	18	195	115	+784
6	Russell Westbrook R. Westbrook	50	2,212	39.0	44.2	9.8	8.3	1.6	0.3	15.5	30.1	51.6	3.1	7.8	40.2	10.1	12.2	82.6	62.4	2.0	7.9	5.0	1,949	491	417	78	15	251	141	+74
7	Damian Lillard D. Lillard	40	1,829	39.8	45.7	4.8	7.9	1.3	0.3	14.5	26.0	55.8	6.5	12.6	51.7	10.2	11.1	92.3	74.1	0.6	4.2	2.5	1,591	190	317	52	13	100	75	+298
8	Anthony Davis A. Davis	36	1,584	40.1	44.0	13.9	2.9	2.2	2.1	15.8	27.7	57.1	1.4	3.4	40.5	11.0	12.7	86.7	66.1	3.8	10.1	1.8	1,444	501	105	78	75	66	90	+319
9	Carmelo Anthony C. Anthony	36	1,586	42.3	44.1	7.6	2.9	1.2	0.6	15.9	27.6	57.7	3.0	5.6	53.2	9.2	10.6	86.4	68.2	2.1	5.4	2.5	1,521	272	103	42	22	91	130	+169
10	Dwyane Wade D. Wade	34	1,467	41.9	43.1	6.2	6.2	2.5	1.4	15.0	26.4	56.8	1.6	3.8	43.4	11.4	14.1	81.2	66.1	1.4	4.8	3.9	1,426	212	212	84	48	134	81	+212
11	Allen Iverson A. Iverson	32	1,438	44.8	44.9	4.0	8.2	2.3	0.1	15.4	29.4	52.6	1.7	4.3	38.4	12.4	14.6	85.0	62.8	0.6	3.4	3.7	1,435	128	262	74	4	117	65	+236
12	Bradley Beal B. Beal	30	1,335	41.1	44.5	4.9	5.4	1.1	0.4	15.8	28.2	56.0	4.6	9.6	48.1	8.3	9.7	85.9	68.5	1.4	3.5	3.1	1,234	146	163	34	12	94	79	+12
13	Giannis Antetokounmpo G. Antetokounmpo	29	1,273	36.5	43.9	12.6	5.3	1.1	1.4	15.6	23.3	66.8	1.7	4.1	40.8	11.0	14.7	75.3	73.7	2.7	9.9	3.1	1,058	365	154	32	40	91	84	+179
14	Gilbert Arenas G. Arenas	28	1,236	42.8	44.1	4.0	5.7	2.0	0.3	13.6	25.6	53.4	4.7	9.6	48.5	12.2	14.6	83.2	68.9	0.9	3.0	3.8	1,198	111	160	55	7	106	93	+152
15	Kyrie Irving K. Irving	27	1,223	39.1	45.3	4.3	5.7	1.8	0.5	16.1	27.2	59.2	5.9	10.1	58.6	7.1	7.7	92.3	73.9	0.8	3.5	2.7	1,055	116	155	48	13	74	78	+242
16	Trae Young T. Young	26	1,148	38.2	44.2	4.3	9.4	0.9	0.2	13.8	24.9	55.6	5.4	11.2	48.6	11.0	12.4	89.1	72.7	0.7	3.7	5.2	994	112	244	24	5	134	45	+193
17	Joel Embiid J. Embiid	26	1,113	36.4	42.8	15.0	4.1	1.3	2.2	14.2	23.8	59.5	1.7	4.1	42.1	12.8	15.2	83.8	70.2	3.2	11.8	3.3	945	390	106	35	58	87	87	+291
18	Tracy McGrady T. McGrady	23	1,010	41.9	43.9	7.2	5.4	1.7	0.8	15.6	29.4	53.0	4.0	8.6	46.0	8.7	11.2	78.2	63.9	1.3	5.9	2.8	965	165	124	40	19	65	41	+76
19	Vince Carter V. Carter	21	906	41.7	43.1	7.9	4.7	1.4	0.9	14.9	26.7	55.6	4.1	7.7	54.0	9.3	11.0	84.1	68.3	1.9	6.0	3.1	877	165	99	29	19	65	62	+201
20	Kemba Walker K. Walker	19	838	39.3	44.1	5.4	5.6	1.3	0.4	14.9	26.3	56.8	5.6	11.0	51.2	8.6	9.6	89.6	72.2	0.7	4.6	2.6	747	102	106	24	8	49	26	+71
21	Devin Booker D. Booker	18	830	38.5	46.1	5.9	6.1	1.2	0.6	16.1	27.6	58.3	3.4	7.9	42.7	10.6	11.8	89.7	70.4	0.8	5.1	3.8	693	107	109	22	10	69	56	+87
22	DeMar DeRozan D. DeRozan	18	765	39.0	42.5	5.9	4.4	1.1	0.3	15.4	26.7	57.8	1.4	3.3	42.4	10.2	12.2	84.0	66.2	1.3	4.6	2.7	701	107	79	19	5	49	38	+139
23	Paul George P. George	18	786	39.5	43.7	8.7	5.1	2.0	0.3	15.0	25.9	57.8	6.1	11.8	51.9	7.6	9.2	82.4	72.8	0.9	7.8	2.7	711	156	92	36	5	49	54	+152
24	Amar'e Stoudemire A. Stoudemire	18	770	39.2	42.8	10.5	2.6	1.2	1.4	15.3	23.2	65.9	0.1	0.4	25.0	12.1	14.4	84.2	72.5	4.2	6.3	2.7	705	189	46	21	25	48	69	+183
25	Dirk Nowitzki D. Nowitzki	18	769	41.8	42.7	9.5	2.5	1.2	1.2	14.2	25.6	55.3	2.6	4.9	53.4	11.8	12.8	92.2	68.4	1.8	7.7	2.4	752	171	45	22	22	43	43	+158