Since 1999-00, Kobe Bryant has the most games with 50+ points, with 25 games.

Interpreted as:

most 50 or more point regular-season games by a player in the since 2000

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Kobe Bryant K. Bryant	25	1,377	44.0	55.1	6.3	3.4	1.6	0.5	18.7	35.0	53.4	4.3	9.4	45.5	13.4	15.1	89.1	66.2	1.0	5.3	2.7	1,101	158	86	39	12	68	67	+285
2	James Harden J. Harden	24	1,307	40.2	54.5	7.8	8.2	2.1	0.6	16.0	30.2	53.1	6.6	14.5	45.7	15.8	17.4	90.4	71.9	1.5	6.3	5.5	964	186	197	51	15	131	75	+308
3	Damian Lillard D. Lillard	15	826	39.4	55.1	4.4	7.4	1.4	0.2	17.0	29.4	57.8	7.7	14.5	53.5	13.3	14.1	94.3	77.3	0.5	3.9	2.4	590	66	111	21	3	36	22	+165
4	Stephen Curry S. Curry	15	801	36.9	53.4	5.5	5.5	1.7	0.4	17.4	28.3	61.6	9.9	16.5	59.7	8.7	9.2	94.9	82.6	0.4	5.1	3.4	553	83	83	25	6	51	26	+142
5	LeBron James L. James	14	744	42.5	53.1	7.9	7.1	1.5	0.9	18.4	30.6	59.9	5.2	9.3	56.2	11.2	13.9	80.5	72.3	1.4	6.4	3.2	595	110	99	21	12	45	31	+135
6	Allen Iverson A. Iverson	10	532	45.3	53.2	4.3	5.5	2.6	0.2	18.8	34.0	55.3	2.5	5.2	48.1	13.1	15.8	82.9	65.0	0.8	3.5	4.1	453	43	55	26	2	41	25	+73
7	Giannis Antetokounmpo G. Antetokounmpo	9	488	36.8	54.2	14.0	4.8	1.3	0.6	18.9	29.2	64.6	1.6	4.4	35.0	14.9	18.7	79.8	72.4	3.1	10.9	3.3	331	126	43	12	5	30	21	+126
8	Kevin Durant K. Durant	9	468	44.2	52.0	7.9	5.6	1.4	0.7	17.2	30.3	56.8	5.4	10.0	54.4	12.1	13.7	88.6	71.5	0.9	7.0	4.2	398	71	50	13	6	38	21	+55
9	Joel Embiid J. Embiid	8	435	35.3	54.4	13.5	4.9	1.0	2.5	19.1	28.6	66.8	0.9	2.5	35.0	15.3	17.0	89.7	75.3	3.8	9.8	2.9	283	108	39	8	20	23	22	+122
10	Devin Booker D. Booker	8	454	38.9	56.8	5.5	5.4	0.9	0.6	19.9	32.3	61.6	5.5	10.8	51.2	11.5	13.0	88.5	74.7	1.0	4.5	3.5	311	44	43	7	5	28	22	+44
11	Luka Dončić L. Dončić	7	388	41.5	55.4	9.7	8.9	2.4	0.9	18.6	28.3	65.7	6.0	11.7	51.2	12.3	15.6	78.9	78.9	1.0	8.7	4.3	291	68	62	17	6	30	20	+60
12	Kyrie Irving K. Irving	6	326	37.9	54.3	4.8	5.3	2.0	0.5	18.0	29.0	62.1	8.2	12.2	67.1	10.2	11.0	92.4	80.3	1.2	3.7	2.2	228	29	32	12	3	13	17	+106
13	Shai Gilgeous-Alexander S. Gilgeous-Alexander	5	262	38.4	52.4	6.4	5.2	1.8	1.0	16.8	30.8	54.5	3.0	7.8	38.5	15.8	17.4	90.8	68.1	1.4	5.0	2.2	192	32	26	9	5	11	15	+67
14	Jayson Tatum J. Tatum	5	269	40.1	53.8	8.4	4.8	0.0	0.4	17.0	28.6	59.4	7.0	11.6	60.3	12.8	14.0	91.4	77.4	1.6	6.8	2.4	201	42	24	0	2	12	13	+69
15	Bradley Beal B. Beal	5	269	40.2	53.8	4.4	3.0	0.8	0.6	18.8	32.6	57.7	5.6	10.6	52.8	10.6	12.2	86.9	70.8	2.4	2.0	4.6	201	22	15	4	3	23	15	+3
16	Anthony Davis A. Davis	5	267	40.0	53.4	15.4	3.8	2.0	2.8	19.8	31.2	63.5	0.8	2.0	40.0	13.0	14.4	90.3	71.1	4.2	11.2	1.8	200	77	19	10	14	9	10	+59
17	Russell Westbrook R. Westbrook	5	270	40.1	54.0	10.8	9.6	2.0	0.2	19.4	39.6	49.0	4.2	12.2	34.4	11.0	13.8	79.7	59.1	2.0	8.8	4.0	200	54	48	10	1	20	16	+28
18	Klay Thompson K. Thompson	4	218	33.6	54.5	4.0	2.3	1.5	0.8	19.0	31.5	60.3	10.8	18.5	58.1	5.8	6.3	92.0	79.6	0.5	3.5	2.3	134	16	9	6	3	9	9	+116
19	Carmelo Anthony C. Anthony	4	212	41.1	53.0	8.0	1.8	0.5	1.0	18.5	28.3	65.5	4.0	7.0	57.1	12.0	13.0	92.3	78.0	1.3	6.8	1.8	164	32	7	2	4	7	11	+49
20	Jamal Crawford J. Crawford	4	203	43.6	50.8	4.3	3.3	1.3	0.8	17.5	30.0	58.3	6.5	10.5	61.9	9.3	10.5	88.1	73.3	0.5	3.8	2.8	174	17	13	5	3	11	11	+49
21	Tracy McGrady T. McGrady	4	215	40.5	53.8	7.8	4.0	2.0	0.8	18.3	32.0	57.0	5.8	11.3	51.1	11.5	16.0	71.9	68.8	1.5	6.3	3.5	162	31	16	8	3	14	9	+36
22	Jalen Brunson J. Brunson	3	166	40.9	55.3	4.3	8.0	2.0	0.0	20.0	33.7	59.4	5.7	11.0	51.5	9.7	10.7	90.6	72.1	0.7	3.7	2.0	123	13	24	6	0	6	3	+28
23	Tyrese Maxey T. Maxey	3	153	44.8	51.0	4.7	4.3	0.7	1.3	18.7	33.3	56.0	5.3	10.0	53.3	8.3	8.7	96.2	68.6	1.0	3.7	1.0	134	14	13	2	4	3	8	+29
24	Nikola Jokić N. Jokić	3	167	44.2	55.7	11.3	10.0	1.3	1.0	20.0	33.7	59.4	4.0	7.7	52.2	11.7	14.7	79.5	69.4	3.3	8.0	3.3	133	34	30	4	3	10	12	+3
25	Karl-Anthony Towns K. Towns	3	178	38.5	59.3	13.3	3.0	0.3	0.3	19.7	32.7	60.2	7.7	11.3	67.6	12.3	15.0	82.2	75.6	3.0	10.3	5.0	115	40	9	1	1	15	11	+23