Kyrie Irving and Karl-Anthony Towns were tied for the most points in a game with 20+ minutes played in 2021-22, with 60 points.

Interpreted as:

most pts by a player in a regular-season game 2022 with 20 or more mins

	NAME	PTS	MIN	DATE	TM		OPP	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Kyrie Irving K. Irving	60	35	3/15/2022	BKN	@	ORL	6	4	4	1	20	31	64.5	8	12	66.7	12	13	92.3	81.7	2	4	1	3	+36
2	Karl-Anthony Towns K. Towns	60	36	3/14/2022	MIN	@	SAS	17	3	1	0	19	31	61.3	7	11	63.6	15	16	93.8	78.9	2	15	6	5	+16
3	LeBron James L. James	56	39	3/5/2022	LAL	vs	GSW	10	3	0	1	19	31	61.3	6	11	54.5	12	13	92.3	76.3	2	8	4	0	+13
4	Trae Young T. Young	56	37	1/3/2022	ATL	@	POR	4	14	0	0	17	26	65.4	7	12	58.3	15	15	100.0	85.9	1	3	4	1	+10
5	Kevin Durant K. Durant	55	42	4/2/2022	BKN	@	ATL	7	3	1	0	19	28	67.9	8	10	80.0	9	11	81.8	83.7	0	7	4	1	+1
6	Jayson Tatum J. Tatum	54	41	3/6/2022	BOS	vs	BKN	5	3	0	0	16	30	53.3	8	15	53.3	14	17	82.4	72.0	2	3	2	4	+12
7	Kevin Durant K. Durant	53	43	3/13/2022	BKN	vs	NYK	6	9	2	0	19	37	51.4	4	13	30.8	11	12	91.7	62.7	1	5	5	3	+11
8	Ja Morant J. Morant	52	34	2/28/2022	MEM	vs	SAS	7	2	0	0	22	30	73.3	4	4	100.0	4	7	57.1	78.6	1	6	4	1	+23
9	Saddiq Bey S. Bey	51	39	3/17/2022	DET	@	ORL	9	4	3	0	17	27	63.0	10	14	71.4	7	10	70.0	81.2	0	9	1	1	+11
10	Luka Dončić L. Dončić	51	40	2/10/2022	DAL	vs	LAC	9	6	1	1	17	26	65.4	7	14	50.0	10	14	71.4	79.3	0	9	7	4	+9
11	Jayson Tatum J. Tatum	51	33	1/23/2022	BOS	@	WAS	10	7	0	0	18	28	64.3	9	14	64.3	6	6	100.0	83.2	2	8	1	1	+31
12	Kevin Durant K. Durant	51	41	12/12/2021	BKN	@	DET	7	9	1	2	16	31	51.6	5	10	50.0	14	15	93.3	67.8	0	7	5	5	+25
13	DeMar DeRozan D. DeRozan	50	43	3/31/2022	CHI	vs	LAC	5	6	1	0	17	26	65.4	2	2	100.0	14	15	93.3	76.7	0	5	2	4	+19
14	LeBron James L. James	50	36	3/11/2022	LAL	vs	WAS	7	6	0	1	18	25	72.0	6	9	66.7	8	8	100.0	87.7	0	7	3	3	+22
15	Kyrie Irving K. Irving	50	37	3/8/2022	BKN	@	CHA	3	6	1	1	15	19	78.9	9	12	75.0	11	13	84.6	101.1	0	3	3	4	+14
16	Giannis Antetokounmpo G. Antetokounmpo	50	36	2/15/2022	MIL	vs	IND	14	4	0	0	17	21	81.0	2	3	66.7	14	18	77.8	86.4	4	10	3	3	+7
17	Joel Embiid J. Embiid	50	27	1/19/2022	PHI	vs	ORL	12	2	1	3	17	23	73.9	1	4	25.0	15	17	88.2	82.0	1	11	2	3	+24
18	Jaylen Brown J. Brown	50	46	1/2/2022	BOS	vs	ORL	11	4	1	2	19	29	65.5	5	10	50.0	7	8	87.5	76.9	0	11	7	4	+10
19	Stephen Curry S. Curry	50	35	11/8/2021	GSW	vs	ATL	7	10	4	1	14	28	50.0	9	19	47.4	13	13	100.0	74.1	2	5	2	0	+31
20	Anthony Edwards A. Edwards	49	39	4/7/2022	MIN	vs	SAS	6	8	1	0	16	28	57.1	6	14	42.9	11	14	78.6	71.7	2	4	2	2	+18
21	Devin Booker D. Booker	49	39	3/24/2022	PHX	@	DEN	4	10	3	1	16	25	64.0	2	5	40.0	15	17	88.2	75.4	0	4	2	3	+16
22	Luka Dončić L. Dončić	49	38	2/17/2022	DAL	@	NOP	15	8	0	1	17	35	48.6	7	14	50.0	8	12	66.7	60.8	1	14	5	3	+21
23	Nikola Jokić N. Jokić	49	41	1/19/2022	DEN	vs	LAC	14	10	3	1	16	25	64.0	3	5	60.0	14	16	87.5	76.5	7	7	5	4	+15
24	Devin Booker D. Booker	48	35	1/17/2022	PHX	@	SAS	5	6	3	0	18	33	54.5	5	13	38.5	7	8	87.5	65.7	0	5	0	2	+3
25	Anthony Edwards A. Edwards	48	42	11/10/2021	MIN	@	GSW	6	5	2	0	16	27	59.3	7	13	53.8	9	12	75.0	74.3	2	4	6	1	-3