Wilt Chamberlain has dropped the most points in a game with 20+ rebounds, with 100 points versus the Knicks on March 2, 1962.

what nba player has the most 40 point 20 rebound games in nba historys in a game
Interpreted as:
What NBA player has the most 40 point 20 or more rebound games in NBA historys in a regular-season game?

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