James Harden has the highest plus/minus in a game with 30+ points, at +50 against the Hawks on November 30, 2019.

Interpreted as:

highest +/- by a player in a regular-season game with 30 or more points

	NAME	+/-	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	James Harden J. Harden	+50	60	11/30/2019	HOU	vs	ATL	31	3	8	3	1	16	24	66.7	8	14	57.1	20	23	87.0	87.9	0	3	5	3
2	Pascal Siakam P. Siakam	+49	36	4/2/2021	TOR	vs	GSW	31	7	5	2	0	14	24	58.3	4	9	44.4	4	4	100.0	69.9	0	7	0	2
3	Kemba Walker K. Walker	+47	46	3/22/2018	CHA	vs	MEM	28	3	4	1	0	13	18	72.2	10	14	71.4	10	10	100.0	102.7	0	3	2	1
4	Jayson Tatum J. Tatum	+46	31	2/1/2023	BOS	vs	BKN	29	9	4	2	1	12	19	63.2	7	12	58.3	0	0		81.6	1	8	1	1
5	Brandon Ingram B. Ingram	+45	34	3/1/2024	NOP	vs	IND	30	8	6	1	0	13	21	61.9	1	2	50.0	7	9	77.8	68.1	1	7	2	3
6	Jayson Tatum J. Tatum	+45	35	11/28/2022	BOS	vs	CHA	30	3	3	2	1	15	28	53.6	4	14	28.6	1	1	100.0	61.5	0	3	0	3
7	Luka Dončić L. Dončić	+45	35	11/20/2019	DAL	vs	GSW	26	10	11	4	0	11	18	61.1	6	10	60.0	7	8	87.5	81.3	1	9	5	3
8	Blake Griffin B. Griffin	+45	33	1/10/2014	LAC	vs	LAL	30	12	4	4	2	12	15	80.0	0	0		9	11	81.8	83.2	2	10	4	2
9	Trey Murphy III T. Murphy III	+44	34	3/5/2024	NOP	@	TOR	29	6	1	1	0	11	17	64.7	10	14	71.4	2	4	50.0	90.6	2	4	0	0
10	Trey Murphy III T. Murphy III	+44	41	3/12/2023	NOP	vs	POR	30	7	1	1	1	13	20	65.0	9	14	64.3	6	6	100.0	90.5	1	6	1	2
11	Reggie Jackson R. Jackson	+44	36	3/3/2022	LAC	vs	LAL	35	8	9	2	0	14	30	46.7	4	8	50.0	4	4	100.0	56.7	2	6	3	5
12	Giannis Antetokounmpo G. Antetokounmpo	+44	32	2/28/2020	MIL	vs	OKC	27	13	6	0	0	13	20	65.0	2	4	50.0	4	5	80.0	72.1	2	11	3	2
13	Michael Porter Jr. M. Porter Jr.	+43	30	2/7/2023	DEN	vs	MIN	29	5	1	1	0	11	15	73.3	4	6	66.7	4	4	100.0	89.5	1	4	1	1
14	Shai Gilgeous-Alexander S. Gilgeous-Alexander	+42	50	2/5/2025	OKC	vs	PHX	34	8	5	2	1	18	29	62.1	3	7	42.9	11	12	91.7	72.9	2	6	1	3
15	Paolo Banchero P. Banchero	+42	33	10/23/2024	ORL	@	MIA	31	11	3	1	1	12	24	50.0	4	8	50.0	5	6	83.3	61.9	4	7	0	2
16	Doug McDermott D. McDermott	+42	31	5/1/2021	IND	@	OKC	27	1	1	1	0	11	14	78.6	6	8	75.0	3	4	75.0	98.4	0	1	0	2
17	Stephen Curry S. Curry	+42	43	1/28/2017	GSW	vs	LAC	29	9	6	0	0	15	23	65.2	9	15	60.0	4	4	100.0	86.8	0	9	2	1
18	Shai Gilgeous-Alexander S. Gilgeous-Alexander	+41	31	1/11/2024	OKC	vs	POR	21	5	4	0	1	11	15	73.3	1	3	33.3	8	8	100.0	83.7	1	4	2	2
19	Luka Dončić L. Dončić	+41	39	4/8/2022	DAL	vs	POR	30	11	7	0	1	12	21	57.1	7	14	50.0	8	11	72.7	75.5	0	11	5	0
20	Amir Coffey A. Coffey	+41	32	4/1/2022	LAC	@	MIL	43	6	7	4	0	10	16	62.5	5	9	55.6	7	7	100.0	83.9	0	6	0	2
21	E'Twaun Moore E. Moore	+41	30	4/4/2018	NOP	vs	MEM	29	1	4	3	1	11	16	68.8	7	10	70.0	1	1	100.0	91.2	0	1	1	3
22	Kobe Bryant K. Bryant	+41	30	1/15/2010	LAL	vs	LAC	37	2	3	1	0	10	20	50.0	4	7	57.1	6	8	75.0	63.8	0	2	1	2
23	Jason Richardson J. Richardson	+41	32	4/15/2007	GSW	vs	MIN	37	12	7	3	1	11	17	64.7	4	7	57.1	6	7	85.7	79.7	4	8	1	2
24	Mikal Bridges M. Bridges	+40	31	12/1/2024	NYK	vs	NOP	36	4	1	0	1	12	19	63.2	7	12	58.3	0	0		81.6	0	4	1	1
25	Amir Coffey A. Coffey	+40	35	4/10/2022	LAC	vs	OKC	43	13	5	0	1	13	22	59.1	7	10	70.0	2	2	100.0	76.5	2	11	2	1