Between the 2009-10 and 2021-22 seasons, James Harden had the most games with 40+ points, with 101 games.

Interpreted as:

most 40 or more point regular-season games by a player 2009-10 to 2021-22

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	James Harden J. Harden	101	4,584	39.6	45.4	7.5	8.2	2.2	0.7	13.3	26.4	50.4	5.6	12.8	43.6	13.2	15.0	88.1	68.8	1.2	6.3	4.9	4,003	757	824	220	75	497	308	+967
2	Kevin Durant K. Durant	58	2,541	41.8	43.8	8.3	4.6	1.2	1.1	14.6	25.9	56.4	3.9	8.0	48.3	10.7	12.1	89.0	70.2	0.9	7.4	3.7	2,427	482	264	69	66	214	138	+377
3	Stephen Curry S. Curry	56	2,527	36.5	45.1	5.4	5.8	1.4	0.3	14.6	25.1	58.2	8.6	15.1	57.1	7.2	7.8	93.1	79.0	0.7	4.7	3.5	2,046	302	326	81	18	195	115	+784
4	Russell Westbrook R. Westbrook	50	2,212	39.0	44.2	9.8	8.3	1.6	0.3	15.5	30.1	51.6	3.1	7.8	40.2	10.1	12.2	82.6	62.4	2.0	7.9	5.0	1,949	491	417	78	15	251	141	+74
5	Damian Lillard D. Lillard	40	1,829	39.8	45.7	4.8	7.9	1.3	0.3	14.5	26.0	55.8	6.5	12.6	51.7	10.2	11.1	92.3	74.1	0.6	4.2	2.5	1,591	190	317	52	13	100	75	+298
6	Anthony Davis A. Davis	36	1,584	40.1	44.0	13.9	2.9	2.2	2.1	15.8	27.7	57.1	1.4	3.4	40.5	11.0	12.7	86.7	66.1	3.8	10.1	1.8	1,444	501	105	78	75	66	90	+319
7	LeBron James L. James	36	1,597	40.4	44.4	9.2	7.0	1.7	1.1	16.1	26.3	61.4	3.8	7.4	51.3	8.3	10.9	76.3	71.4	1.7	7.5	3.5	1,454	330	252	60	40	127	60	+338
8	Bradley Beal B. Beal	30	1,335	41.1	44.5	4.9	5.4	1.1	0.4	15.8	28.2	56.0	4.6	9.6	48.1	8.3	9.7	85.9	68.5	1.4	3.5	3.1	1,234	146	163	34	12	94	79	+12
9	Giannis Antetokounmpo G. Antetokounmpo	29	1,273	36.5	43.9	12.6	5.3	1.1	1.4	15.6	23.3	66.8	1.7	4.1	40.8	11.0	14.7	75.3	73.7	2.7	9.9	3.1	1,058	365	154	32	40	91	84	+179
10	Kyrie Irving K. Irving	27	1,223	39.1	45.3	4.3	5.7	1.8	0.5	16.1	27.2	59.2	5.9	10.1	58.6	7.1	7.7	92.3	73.9	0.8	3.5	2.7	1,055	116	155	48	13	74	78	+242
11	Trae Young T. Young	26	1,148	38.2	44.2	4.3	9.4	0.9	0.2	13.8	24.9	55.6	5.4	11.2	48.6	11.0	12.4	89.1	72.7	0.7	3.7	5.2	994	112	244	24	5	134	45	+193
12	Joel Embiid J. Embiid	26	1,113	36.4	42.8	15.0	4.1	1.3	2.2	14.2	23.8	59.5	1.7	4.1	42.1	12.8	15.2	83.8	70.2	3.2	11.8	3.3	945	390	106	35	58	87	87	+291
13	Kobe Bryant K. Bryant	26	1,105	41.1	42.5	5.8	4.6	1.7	0.4	15.1	28.7	52.5	2.4	6.1	39.2	10.0	11.8	84.1	62.6	1.0	4.8	3.7	1,070	150	120	43	11	97	60	+81
14	Carmelo Anthony C. Anthony	26	1,149	42.4	44.2	7.4	3.1	0.7	0.6	15.8	27.8	56.6	3.4	6.6	52.0	9.2	10.6	87.3	68.0	2.0	5.4	2.4	1,103	193	81	19	16	62	92	+107
15	Kemba Walker K. Walker	19	838	39.3	44.1	5.4	5.6	1.3	0.4	14.9	26.3	56.8	5.6	11.0	51.2	8.6	9.6	89.6	72.2	0.7	4.6	2.6	747	102	106	24	8	49	26	+71
16	Devin Booker D. Booker	18	830	38.5	46.1	5.9	6.1	1.2	0.6	16.1	27.6	58.3	3.4	7.9	42.7	10.6	11.8	89.7	70.4	0.8	5.1	3.8	693	107	109	22	10	69	56	+87
17	DeMar DeRozan D. DeRozan	18	765	39.0	42.5	5.9	4.4	1.1	0.3	15.4	26.7	57.8	1.4	3.3	42.4	10.2	12.2	84.0	66.2	1.3	4.6	2.7	701	107	79	19	5	49	38	+139
18	Paul George P. George	18	786	39.5	43.7	8.7	5.1	2.0	0.3	15.0	25.9	57.8	6.1	11.8	51.9	7.6	9.2	82.4	72.8	0.9	7.8	2.7	711	156	92	36	5	49	54	+152
19	Luka Dončić L. Dončić	15	647	38.6	43.1	9.5	9.6	1.0	0.4	14.5	26.9	54.1	5.0	11.1	44.9	9.1	11.6	78.2	67.5	1.0	8.5	4.8	579	143	144	15	6	72	46	+153
20	Zach LaVine Z. LaVine	15	652	39.7	43.5	6.2	3.9	1.3	0.3	16.0	27.1	59.0	6.7	12.3	54.3	4.8	5.9	80.9	73.1	1.0	5.2	4.1	595	93	58	20	5	61	40	+49
21	Klay Thompson K. Thompson	14	624	32.4	44.6	3.4	1.8	1.0	0.8	15.6	24.7	63.3	8.1	13.6	59.7	5.1	5.6	92.3	82.0	0.3	3.1	1.6	453	47	25	14	11	23	17	+352
22	DeMarcus Cousins D. Cousins	13	574	39.5	44.2	15.8	4.0	1.5	1.5	14.8	26.3	56.4	2.5	5.5	45.1	12.0	15.0	80.0	67.1	3.9	11.8	4.5	514	205	52	20	20	58	57	+89
23	Nikola Jokić N. Jokić	12	532	38.7	44.3	10.7	6.9	1.7	1.2	17.0	26.9	63.2	3.0	5.8	52.2	7.3	8.7	84.6	72.1	3.3	7.3	2.7	465	128	83	20	14	32	36	+106
24	Jayson Tatum J. Tatum	11	511	37.8	46.5	7.0	4.1	1.1	0.7	15.5	25.7	60.4	6.1	10.3	59.3	9.3	10.3	90.3	76.8	0.9	6.1	1.8	416	77	45	12	8	20	28	+187
25	Karl-Anthony Towns K. Towns	11	488	36.9	44.4	14.4	3.8	0.8	0.6	16.0	26.2	61.1	3.5	6.3	55.1	8.9	10.9	81.7	71.6	3.6	10.7	3.1	405	158	42	9	7	34	36	+62