Steve Nash has the most assists in a game versus LeBron James, with 21 assists against the Cavaliers on January 11, 2007.

Interpreted as:

most assists by a player in a regular-season game vs LeBron James

	NAME	AST	DATE	TM		OPP	MIN	PTS	REB	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Steve Nash S. Nash	21	1/11/2007	PHX	vs	CLE	30	4	4	1	0	2	7	28.6	0	1	0.0	0	0		28.6	0	4	1	2	+21
2	Trae Young T. Young	20	12/6/2024	ATL	vs	LAL	42	31	4	2	0	9	25	36.0	5	13	38.5	8	8	100.0	54.3	0	4	3	1	-6
3	Russell Westbrook R. Westbrook	20	1/20/2018	OKC	@	CLE	35	23	9	2	0	9	17	52.9	1	1	100.0	4	5	80.0	59.9	2	7	5	1	+26
4	Chris Paul C. Paul	20	3/26/2008	NOH	@	CLE	42	15	3	2	1	5	17	29.4	1	4	25.0	4	4	100.0	40.0	2	1	1	2	+5
5	Brevin Knight B. Knight	20	1/11/2005	CHA	@	CLE	40	15	3	2	0	4	9	44.4	0	0		7	7	100.0	62.1	0	3	5	3	+3
6	Chris Paul C. Paul	19	11/5/2010	NOH	vs	MIA	36	13	2	5	0	5	13	38.5	0	2	0.0	3	3	100.0	45.4	0	2	3	4	+9
7	Tyrese Haliburton T. Haliburton	18	3/26/2025	IND	vs	LAL	32	16	0	2	1	7	16	43.8	1	9	11.1	1	1	100.0	48.7	0	0	1	2	+7
8	Steve Nash S. Nash	18	12/23/2010	PHX	vs	MIA	32	4	4	0	0	1	4	25.0	0	2	0.0	2	2	100.0	41.0	0	4	5	1	0
9	Josh Giddey J. Giddey	17	3/22/2025	CHI	@	LAL	33	15	10	8	0	5	11	45.5	1	2	50.0	4	6	66.7	55.0	3	7	2	3	+22
10	Luka Dončić L. Dončić	17	12/12/2023	DAL	vs	LAL	43	33	6	1	0	12	28	42.9	3	10	30.0	6	6	100.0	53.9	0	6	4	0	+10
11	Darius Garland D. Garland	17	3/21/2022	CLE	vs	LAL	41	29	2	1	0	10	23	43.5	2	8	25.0	7	7	100.0	55.6	0	2	1	2	+1
12	Kobe Bryant K. Bryant	17	1/15/2015	LAL	vs	CLE	32	19	6	0	0	7	14	50.0	3	6	50.0	2	3	66.7	62.0	1	5	3	0	+3
13	Rajon Rondo R. Rondo	17	10/26/2010	BOS	vs	MIA	41	4	5	2	0	2	9	22.2	0	0		0	0		22.2	1	4	3	1	+4
14	Steve Nash S. Nash	17	11/10/2004	PHX	@	CLE	50	15	7	0	0	5	13	38.5	1	3	33.3	4	6	66.7	48.0	1	6	1	5	+1
15	Desmond Bane D. Bane	16	3/27/2024	MEM	vs	LAL	40	26	4	1	0	8	17	47.1	4	9	44.4	6	6	100.0	66.2	0	4	4	5	-7
16	Fred VanVleet F. VanVleet	16	11/19/2023	HOU	@	LAL	40	15	1	1	0	5	14	35.7	3	10	30.0	2	2	100.0	50.4	0	1	3	1	+4
17	Trae Young T. Young	16	2/1/2021	ATL	vs	LAL	39	25	4	2	0	7	15	46.7	1	4	25.0	10	11	90.9	63.0	0	4	7	3	-2
18	Ricky Rubio R. Rubio	16	2/14/2017	MIN	vs	CLE	39	5	8	2	0	2	8	25.0	0	2	0.0	1	2	50.0	28.2	1	7	4	3	+1
19	Rajon Rondo R. Rondo	16	2/8/2016	SAC	@	CLE	33	7	8	3	0	1	8	12.5	1	4	25.0	4	8	50.0	30.4	1	7	6	1	-17
20	Rajon Rondo R. Rondo	16	11/14/2014	BOS	vs	CLE	31	6	8	3	0	3	10	30.0	0	0		0	0		30.0	0	8	3	4	-1
21	Jose Calderon J. Calderon	16	3/30/2012	TOR	vs	MIA	42	9	6	1	0	4	8	50.0	0	1	0.0	1	2	50.0	50.7	0	6	3	2	-13
22	Rajon Rondo R. Rondo	16	11/11/2010	BOS	@	MIA	40	8	3	2	0	3	8	37.5	0	0		2	4	50.0	41.0	2	1	3	3	+8
23	Deron Williams D. Williams	16	1/24/2009	UTA	vs	CLE	35	17	4	1	0	5	14	35.7	1	4	25.0	6	9	66.7	47.3	0	4	1	0	-11
24	Allen Iverson A. Iverson	16	4/8/2005	PHI	vs	CLE	46	23	7	5	0	9	30	30.0	1	4	25.0	4	4	100.0	36.2	1	6	8	2	+14
25	Luka Dončić L. Dončić	15	11/1/2019	DAL	vs	LAL	38	31	13	0	1	10	23	43.5	4	9	44.4	7	8	87.5	58.4	1	12	6	3	-4