Wilt Chamberlain has the most points in a game with 54+ minutes played, with 78 points versus the Lakers on December 8, 1961.

Interpreted as:

most points by a player in 54 or more mins in a regular-season game

	NAME	PTS	MIN	DATE	TM		OPP	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	78	63	12/8/1961	PHI	vs	LAL	43	1			31	62	50.0				16	31	51.6	51.6				4
2	Wilt Chamberlain W. Chamberlain	59	58	12/25/1961	PHI	@	NYK	36	0			23	44	52.3				13	22	59.1	55.0				3
3	Kobe Bryant K. Bryant	58	54	12/29/2006	LAL	@	CHA	5	4	0	0	22	45	48.9	4	11	36.4	10	12	83.3	57.7	0	5	4	6	+5
4	Wilt Chamberlain W. Chamberlain	56	58	12/1/1964	SFW	vs	BAL	29	3			22	48	45.8				12	20	60.0	49.3				4
5	Wilt Chamberlain W. Chamberlain	56	58	2/16/1963	SFW	@	LAL	21	3			26	47	55.3				4	11	36.4	54.0				1
6	Kobe Bryant K. Bryant	53	54	12/15/2006	LAL	vs	HOU	10	8	2	1	17	38	44.7	5	8	62.5	14	16	87.5	58.8	0	10	5	1	+20
7	Dale Ellis D. Ellis	53	69	11/9/1989	SEA	@	MIL	7	1	1	1	18	39	46.2	3	7	42.9	14	17	82.4	57.0	2	5	8	4
8	Kobe Bryant K. Bryant	52	54	2/18/2003	LAL	vs	HOU	8	7	0	3	19	38	50.0	3	9	33.3	11	11	100.0	60.7	0	8	5	4	+13
9	Wilt Chamberlain W. Chamberlain	52	58	11/6/1964	SFW	vs	NYK	21	3			21	43	48.8				10	22	45.5	49.4				1
10	Richard Hamilton R. Hamilton	51	55	12/27/2006	DET	@	NYK	2	2	0	0	19	37	51.4	1	1	100.0	12	12	100.0	60.3	0	2	1	4	+2
11	Paul Pierce P. Pierce	50	54	2/15/2006	BOS	vs	CLE	7	8	0	0	17	36	47.2	0	4	0.0	16	20	80.0	55.8	0	7	4	6	-1
12	George Gervin G. Gervin	50	56	3/6/1982	SAS	vs	MIL	8	5	1	0	21	31	67.7	0	0		8	8	100.0	72.4	1	7	4	3
13	Trae Young T. Young	49	56	3/1/2019	ATL	vs	CHI	8	16	1	1	17	33	51.5	6	13	46.2	9	11	81.8	64.7	1	7	9	2	-9
14	Larry Bird L. Bird	49	54	3/15/1992	BOS	vs	POR	14	12	4	1	19	35	54.3	2	8	25.0	9	10	90.0	62.2	0	14	5	5
15	Jerry West J. West	49	55	2/17/1968	LAL	vs	PHI	6	8			19	32	59.4				11	14	78.6	64.2				5
16	Latrell Sprewell L. Sprewell	48	54	1/26/2002	NYK	@	MIL	7	6	2	0	17	36	47.2	9	14	64.3	5	7	71.4	61.4	3	4	6	2	-2
17	Bob Pettit B. Pettit	48	54	3/7/1961	STL	vs	LAL	13				15	39	38.5				18	20	90.0	50.2				2
18	Zach LaVine Z. LaVine	47	56	3/1/2019	CHI	@	ATL	9	9	2	0	17	35	48.6	6	14	42.9	7	11	63.6	59.0	2	7	8	3	+5
19	Allen Iverson A. Iverson	47	54	2/2/2001	PHI	vs	ORL	5	7	2	2	15	35	42.9	2	4	50.0	15	19	78.9	54.2	1	4	5	4	-6
20	Elgin Baylor E. Baylor	46	54	2/16/1963	LAL	vs	SFW	23	6			17	38	44.7				12	15	80.0	51.6				5
21	Ricky Davis R. Davis	45	55	12/9/2002	CLE	vs	MIL	8	5	0	0	16	33	48.5	6	8	75.0	7	8	87.5	61.6	2	6	6	2	-5
22	Mike Mitchell M. Mitchell	45	58	3/6/1982	SAS	vs	MIL	11	1	2	2	17	28	60.7	0	0		11	11	100.0	68.5	5	6	1	3
23	Jalen Rose J. Rose	44	56	3/16/2002	CHI	@	HOU	11	6	2	1	18	34	52.9	3	4	75.0	5	5	100.0	60.8	2	9	1	1	-1
24	Bernard King B. King	44	56	2/26/1991	WAS	@	NYK	12	6	4	0	16	38	42.1	0	3	0.0	12	14	85.7	49.8	4	8	4	3
25	Billy Cunningham B. Cunningham	44	55	1/22/1969	PHI	vs	NYK	11	3			17	33	51.5				10	12	83.3	57.5				2