Since 2021-22, Santi Aldama has the highest plus/minus in a game, at +52 against the Thunder on December 2, 2021.

Interpreted as:

best +- by a player in a regular-season game last 5 seasons

	NAME	+/-	DATE	TM		OPP	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Santi Aldama S. Aldama	+52	12/2/2021	MEM	vs	OKC	28	18	10	3	1	1	8	16	50.0	0	3	0.0	2	3	66.7	52.0	5	5	0	1
2	Ivica Zubac I. Zubac	+48	1/15/2025	LAC	vs	BKN	22	11	9	4	1	1	4	6	66.7	0	0		3	3	100.0	75.1	3	6	2	2
3	Donovan Mitchell D. Mitchell	+47	2/2/2025	CLE	vs	DAL	24	12	6	6	0	0	4	9	44.4	2	5	40.0	2	2	100.0	60.7	0	6	2	2
4	Evan Mobley E. Mobley	+47	2/2/2025	CLE	vs	DAL	24	22	11	3	0	4	8	12	66.7	2	3	66.7	4	5	80.0	77.5	0	11	0	2
5	Norman Powell N. Powell	+47	1/15/2025	LAC	vs	BKN	22	18	1	2	3	0	7	10	70.0	3	4	75.0	1	2	50.0	82.7	0	1	3	3
6	Jaren Jackson Jr. J. Jackson Jr.	+47	3/8/2022	MEM	vs	NOP	24	22	3	0	1	3	7	13	53.8	2	6	33.3	6	6	100.0	70.3	0	3	0	4
7	Bam Adebayo B. Adebayo	+46	4/11/2025	MIA	@	NOP	22	23	12	4	2	0	8	12	66.7	4	6	66.7	3	4	75.0	83.6	3	9	0	1
8	Tyler Herro T. Herro	+46	4/11/2025	MIA	@	NOP	22	22	4	4	1	0	7	10	70.0	2	3	66.7	6	6	100.0	87.0	1	3	1	0
9	Kawhi Leonard K. Leonard	+46	1/15/2025	LAC	vs	BKN	24	23	2	0	1	0	8	11	72.7	0	1	0.0	7	7	100.0	81.7	0	2	1	0
10	Josh Giddey J. Giddey	+46	1/11/2024	OKC	vs	POR	23	13	10	12	0	3	5	5	100.0	0	0		3	3	100.0	102.8	0	10	1	0
11	Josh Hart J. Hart	+46	1/5/2024	NYK	@	PHI	30	10	15	6	0	1	4	7	57.1	0	2	0.0	2	2	100.0	63.5	3	12	2	2
12	Jayson Tatum J. Tatum	+46	2/1/2023	BOS	vs	BKN	29	31	9	4	2	1	12	19	63.2	7	12	58.3	0	0		81.6	1	8	1	1
13	Obi Toppin O. Toppin	+46	4/3/2022	NYK	@	ORL	35	20	8	3	0	1	7	16	43.8	4	10	40.0	2	2	100.0	59.2	1	7	2	1
14	Terry Rozier T. Rozier	+46	2/25/2022	CHA	vs	TOR	32	23	4	9	1	1	10	16	62.5	3	7	42.9	0	0		71.9	0	4	0	3
15	De'Anthony Melton D. Melton	+46	12/2/2021	MEM	vs	OKC	22	19	6	5	0	0	8	10	80.0	3	5	60.0	0	0		95.0	1	5	1	0
16	Toumani Camara T. Camara	+45	2/22/2025	POR	vs	CHA	28	20	10	6	1	2	7	9	77.8	4	6	66.7	2	2	100.0	101.2	1	9	2	3
17	Brandon Ingram B. Ingram	+45	3/1/2024	NOP	vs	IND	30	34	8	6	1	0	13	21	61.9	1	2	50.0	7	9	77.8	68.1	1	7	2	3
18	Luguentz Dort L. Dort	+45	1/11/2024	OKC	vs	POR	19	11	3	1	1	1	3	7	42.9	3	5	60.0	2	2	100.0	69.8	0	3	1	2
19	Jayson Tatum J. Tatum	+45	11/28/2022	BOS	vs	CHA	30	35	3	3	2	1	15	28	53.6	4	14	28.6	1	1	100.0	61.5	0	3	0	3
20	LaMelo Ball L. Ball	+45	1/26/2022	CHA	@	IND	38	29	10	13	1	1	11	16	68.8	3	4	75.0	4	5	80.0	79.7	1	9	4	3
21	Trey Murphy III T. Murphy III	+44	3/5/2024	NOP	@	TOR	29	34	6	1	1	0	11	17	64.7	10	14	71.4	2	4	50.0	90.6	2	4	0	0
22	Derrick White D. White	+44	2/14/2024	BOS	vs	BKN	28	27	5	4	1	0	10	16	62.5	5	10	50.0	2	2	100.0	80.0	0	5	2	2
23	Trey Murphy III T. Murphy III	+44	3/12/2023	NOP	vs	POR	30	41	7	1	1	1	13	20	65.0	9	14	64.3	6	6	100.0	90.5	1	6	1	2
24	Marcus Smart M. Smart	+44	11/28/2022	BOS	vs	CHA	31	22	2	15	2	0	8	11	72.7	6	9	66.7	0	0		100.0	0	2	3	0
25	Domantas Sabonis D. Sabonis	+44	11/15/2022	SAC	vs	BKN	28	17	7	7	1	1	6	6	100.0	0	0		5	5	100.0	103.7	1	6	3	4