James Harden has the highest plus/minus in a game with 25+ points, at +50 against the Hawks on November 30, 2019.

Interpreted as:

highest +/- by a player in a regular-season game with 25 or more points

	NAME	+/-	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	James Harden J. Harden	+50	60	11/30/2019	HOU	vs	ATL	31	3	8	3	1	16	24	66.7	8	14	57.1	20	23	87.0	87.9	0	3	5	3
2	Domantas Sabonis D. Sabonis	+49	26	5/1/2021	IND	@	OKC	30	19	14	1	0	10	13	76.9	2	3	66.7	4	6	66.7	83.1	0	19	5	2
3	Pascal Siakam P. Siakam	+49	36	4/2/2021	TOR	vs	GSW	31	7	5	2	0	14	24	58.3	4	9	44.4	4	4	100.0	69.9	0	7	0	2
4	Amar'e Stoudemire A. Stoudemire	+49	25	2/2/2009	PHX	vs	SAC	28	8	0	1	0	6	12	50.0	0	0		13	13	100.0	70.5	3	5	2	3
5	Caris LeVert C. LeVert	+47	25	5/1/2021	IND	@	OKC	27	1	6	1	2	9	15	60.0	4	6	66.7	3	3	100.0	76.6	0	1	1	3
6	Kemba Walker K. Walker	+47	46	3/22/2018	CHA	vs	MEM	28	3	4	1	0	13	18	72.2	10	14	71.4	10	10	100.0	102.7	0	3	2	1
7	Amar'e Stoudemire A. Stoudemire	+47	25	1/21/2007	PHX	vs	MIN	28	8	1	1	1	11	14	78.6	0	0		3	3	100.0	81.6	3	5	0	3
8	Jayson Tatum J. Tatum	+46	31	2/1/2023	BOS	vs	BKN	29	9	4	2	1	12	19	63.2	7	12	58.3	0	0		81.6	1	8	1	1
9	Juancho Hernangomez J. Hernangomez	+46	25	11/15/2018	DEN	vs	ATL	31	9	1	1	0	9	12	75.0	2	5	40.0	5	7	71.4	82.9	4	5	1	3
10	Brandon Ingram B. Ingram	+45	34	3/1/2024	NOP	vs	IND	30	8	6	1	0	13	21	61.9	1	2	50.0	7	9	77.8	68.1	1	7	2	3
11	Jayson Tatum J. Tatum	+45	35	11/28/2022	BOS	vs	CHA	30	3	3	2	1	15	28	53.6	4	14	28.6	1	1	100.0	61.5	0	3	0	3
12	LaMelo Ball L. Ball	+45	29	1/26/2022	CHA	@	IND	38	10	13	1	1	11	16	68.8	3	4	75.0	4	5	80.0	79.7	1	9	4	3
13	Luka Dončić L. Dončić	+45	35	11/20/2019	DAL	vs	GSW	26	10	11	4	0	11	18	61.1	6	10	60.0	7	8	87.5	81.3	1	9	5	3
14	Blake Griffin B. Griffin	+45	33	1/10/2014	LAC	vs	LAL	30	12	4	4	2	12	15	80.0	0	0		9	11	81.8	83.2	2	10	4	2
15	Luol Deng L. Deng	+45	27	1/11/2010	CHI	vs	DET	33	6	1	0	1	13	18	72.2	1	1	100.0	0	1	0.0	73.2	1	5	0	1
16	Trey Murphy III T. Murphy III	+44	34	3/5/2024	NOP	@	TOR	29	6	1	1	0	11	17	64.7	10	14	71.4	2	4	50.0	90.6	2	4	0	0
17	Derrick White D. White	+44	27	2/14/2024	BOS	vs	BKN	28	5	4	1	0	10	16	62.5	5	10	50.0	2	2	100.0	80.0	0	5	2	2
18	Trey Murphy III T. Murphy III	+44	41	3/12/2023	NOP	vs	POR	30	7	1	1	1	13	20	65.0	9	14	64.3	6	6	100.0	90.5	1	6	1	2
19	Reggie Jackson R. Jackson	+44	36	3/3/2022	LAC	vs	LAL	35	8	9	2	0	14	30	46.7	4	8	50.0	4	4	100.0	56.7	2	6	3	5
20	Giannis Antetokounmpo G. Antetokounmpo	+44	32	2/28/2020	MIL	vs	OKC	27	13	6	0	0	13	20	65.0	2	4	50.0	4	5	80.0	72.1	2	11	3	2
21	Klay Thompson K. Thompson	+44	25	2/27/2015	GSW	@	TOR	28	1	5	1	1	9	18	50.0	5	8	62.5	2	2	100.0	66.2	0	1	0	2
22	Mikal Bridges M. Bridges	+43	28	1/27/2025	NYK	vs	MEM	34	5	6	1	2	12	19	63.2	2	6	33.3	2	2	100.0	70.4	1	4	2	2
23	Victor Wembanyama V. Wembanyama	+43	25	10/31/2024	SAS	@	UTA	34	9	7	5	5	9	20	45.0	4	13	30.8	3	3	100.0	58.6	2	7	3	3
24	Trey Murphy III T. Murphy III	+43	27	12/13/2023	NOP	@	WAS	33	6	4	2	1	7	10	70.0	6	7	85.7	7	8	87.5	99.9	0	6	0	0
25	Michael Porter Jr. M. Porter Jr.	+43	30	2/7/2023	DEN	vs	MIN	29	5	1	1	0	11	15	73.3	4	6	66.7	4	4	100.0	89.5	1	4	1	1