I couldn't find anything for this season, but Shai Gilgeous-Alexander had the highest plus/minus with more than 21.0 points per game in 2024-25, at +918.

Interpreted as:

most +/- by a player this season ppg >21

	NAME	+/-	PPG	SEASON	TM	GP	MPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	PTS	REB	AST	STL	BLK	TOV	PF
1	Shai Gilgeous-Alexander S. Gilgeous-Alexander	+918	32.7	2024-25	OKC	76	34.2	5.0	6.4	1.7	1.0	11.3	21.8	51.9	2.1	5.7	37.5	7.9	8.8	89.8	63.7	0.9	4.1	2.4	2,598	2,484	379	486	131	77	183	164
2	Nikola Jokić N. Jokić	+594	29.6	2024-25	DEN	70	36.7	12.7	10.2	1.8	0.6	11.2	19.5	57.6	2.0	4.7	41.7	5.2	6.4	80.0	66.3	2.9	9.9	3.3	2,571	2,071	892	716	127	45	230	160
3	Jayson Tatum J. Tatum	+534	26.8	2024-25	BOS	72	36.4	8.7	6.0	1.1	0.5	9.2	20.3	45.2	3.5	10.1	34.3	5.0	6.1	81.4	58.2	0.7	8.0	2.9	2,624	1,932	623	431	76	38	209	157
4	Donovan Mitchell D. Mitchell	+522	24.0	2024-25	CLE	71	31.4	4.5	5.0	1.3	0.2	8.2	18.6	44.3	3.3	8.9	36.8	4.2	5.1	82.3	57.5	0.8	3.7	2.1	2,232	1,701	322	354	95	17	149	140
5	Jalen Williams J. Williams	+456	21.6	2024-25	OKC	69	32.4	5.3	5.1	1.6	0.7	8.2	16.9	48.4	1.8	4.9	36.5	3.4	4.3	78.9	57.3	0.9	4.5	2.2	2,237	1,490	369	354	111	46	150	158
6	Jaylen Brown J. Brown	+402	22.2	2024-25	BOS	63	34.3	5.8	4.5	1.2	0.3	8.2	17.7	46.3	1.8	5.7	32.4	3.9	5.1	76.4	55.5	1.3	4.5	2.6	2,158	1,398	368	286	73	19	162	154
7	Karl-Anthony Towns K. Towns	+378	24.4	2024-25	NYK	72	35.0	12.8	3.1	1.0	0.7	8.9	16.9	52.6	2.0	4.7	42.0	4.7	5.7	82.9	63.0	2.9	9.8	2.7	2,517	1,759	920	222	71	50	192	249
8	Norman Powell N. Powell	+352	21.8	2024-25	LAC	60	32.6	3.2	2.1	1.2	0.2	7.6	15.8	48.4	3.0	7.1	41.8	3.6	4.4	80.4	61.5	0.4	2.8	1.8	1,958	1,306	190	125	73	9	108	114
9	James Harden J. Harden	+344	22.8	2024-25	LAC	79	35.3	5.8	8.7	1.5	0.7	6.7	16.4	41.0	3.0	8.5	35.2	6.4	7.3	87.4	58.2	0.7	5.1	4.3	2,789	1,802	456	687	118	55	341	162
10	Luka Dončić L. Dončić	+344	28.2	2024-25	TOT	50	35.4	8.2	7.7	1.8	0.4	9.2	20.5	45.0	3.5	9.6	36.8	6.2	7.9	78.2	58.7	0.8	7.4	3.6	1,769	1,408	409	383	89	21	179	126
11	Giannis Antetokounmpo G. Antetokounmpo	+334	30.4	2024-25	MIL	67	34.2	11.9	6.5	0.9	1.2	11.8	19.7	60.1	0.2	0.9	22.2	6.5	10.6	61.7	62.5	2.2	9.7	3.1	2,289	2,036	798	433	58	78	206	155
12	Jamal Murray J. Murray	+331	21.4	2024-25	DEN	67	36.1	3.9	6.0	1.4	0.5	7.9	16.7	47.4	2.3	5.9	39.3	3.3	3.7	88.6	58.4	0.7	3.2	2.1	2,418	1,436	261	403	91	33	138	128
13	Jaren Jackson Jr. J. Jackson Jr.	+330	22.2	2024-25	MEM	74	29.8	5.6	2.0	1.2	1.5	8.0	16.4	48.8	2.0	5.3	37.5	4.2	5.4	78.1	59.1	1.2	4.4	2.1	2,207	1,641	417	148	92	113	153	257
14	Stephen Curry S. Curry	+299	24.5	2024-25	GSW	70	32.2	4.4	6.0	1.1	0.4	8.1	18.0	44.8	4.4	11.2	39.7	4.0	4.3	93.3	61.8	0.6	3.9	2.9	2,252	1,718	310	421	80	30	200	95
15	Kawhi Leonard K. Leonard	+296	21.5	2024-25	LAC	37	31.9	5.9	3.1	1.6	0.5	8.4	16.8	49.8	2.1	5.1	41.1	2.6	3.3	81.0	58.9	0.9	5.0	1.9	1,180	796	219	116	59	17	72	56
16	Anthony Edwards A. Edwards	+291	27.6	2024-25	MIN	79	36.3	5.7	4.5	1.2	0.6	9.1	20.4	44.7	4.1	10.3	39.5	5.3	6.3	83.7	59.5	0.8	4.9	3.2	2,871	2,177	450	359	91	51	249	150
17	Franz Wagner F. Wagner	+248	24.2	2024-25	ORL	60	33.7	5.7	4.7	1.3	0.4	9.0	19.4	46.3	1.7	5.9	29.5	4.5	5.2	87.1	55.8	0.9	4.8	2.3	2,023	1,449	342	284	75	21	138	147
18	Ja Morant J. Morant	+226	23.2	2024-25	MEM	50	30.4	4.1	7.3	1.2	0.2	8.1	17.8	45.4	1.8	5.7	30.9	5.3	6.4	82.4	56.3	0.7	3.4	3.7	1,519	1,159	205	364	61	12	185	113
19	Cade Cunningham C. Cunningham	+175	26.1	2024-25	DET	70	35.0	6.1	9.1	1.0	0.8	9.8	20.8	46.9	2.1	6.0	35.6	4.5	5.3	84.6	56.5	0.8	5.3	4.4	2,452	1,830	425	638	71	53	309	195
20	Jalen Green J. Green	+166	21.0	2024-25	HOU	82	32.9	4.6	3.4	0.9	0.3	7.4	17.5	42.3	2.9	8.1	35.4	3.3	4.1	81.3	54.4	0.5	4.0	2.5	2,697	1,723	377	282	71	27	203	127
21	Jalen Brunson J. Brunson	+146	26.0	2024-25	NYK	65	35.4	2.9	7.3	0.9	0.1	9.0	18.5	48.8	2.3	6.1	38.3	5.7	6.9	82.1	60.5	0.4	2.5	2.5	2,301	1,690	187	475	60	8	164	138
22	Kyrie Irving K. Irving	+124	24.7	2024-25	DAL	50	36.1	4.8	4.6	1.3	0.5	8.9	18.9	47.3	2.9	7.2	40.1	3.9	4.3	91.6	59.4	1.2	3.6	2.2	1,804	1,234	240	231	66	23	111	101
23	DeMar DeRozan D. DeRozan	+110	22.2	2024-25	SAC	77	35.9	3.9	4.4	0.8	0.4	8.1	17.0	47.7	1.1	3.3	32.8	4.9	5.7	85.7	56.9	0.6	3.2	1.4	2,768	1,710	298	342	62	32	105	150
24	Victor Wembanyama V. Wembanyama	+102	24.3	2024-25	SAS	46	33.2	11.0	3.7	1.1	3.8	8.9	18.6	47.6	3.1	8.8	35.2	3.4	4.1	83.6	59.4	1.8	9.2	3.2	1,527	1,116	506	168	52	176	149	105
25	Tyler Herro T. Herro	+99	23.9	2024-25	MIA	77	35.4	5.2	5.5	0.9	0.2	8.5	17.9	47.2	3.3	8.7	37.5	3.7	4.2	87.8	60.5	0.5	4.7	2.6	2,725	1,840	399	424	69	17	198	85