I couldn't find anything for this season, but Nikola Jokić had the highest plus/minus by a center in 2024-25, at +594.

	NAME	+/-	SEASON	TM	GP	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	PTS	REB	AST	STL	BLK	TOV	PF
1	Nikola Jokić N. Jokić	+594	2024-25	DEN	70	36.7	29.6	12.7	10.2	1.8	0.6	11.2	19.5	57.6	2.0	4.7	41.7	5.2	6.4	80.0	66.3	2.9	9.9	3.3	2,571	2,071	892	716	127	45	230	160
2	Ivica Zubac I. Zubac	+514	2024-25	LAC	80	32.8	16.8	12.6	2.7	0.7	1.1	7.4	11.8	62.8	0.0	0.0		2.0	3.0	66.1	64.1	3.8	8.9	1.6	2,624	1,340	1,010	214	55	90	127	168
3	Jarrett Allen J. Allen	+514	2024-25	CLE	82	28.0	13.5	9.7	1.9	0.9	0.9	5.5	7.8	70.6	0.0	0.1	0.0	2.4	3.4	71.8	72.4	2.6	7.1	1.2	2,296	1,103	798	158	77	73	97	127
4	Isaiah Hartenstein I. Hartenstein	+417	2024-25	OKC	57	27.9	11.2	10.7	3.8	0.8	1.1	4.9	8.4	58.1	0.0	0.3	0.0	1.4	2.1	67.5	59.9	2.9	7.9	1.7	1,590	637	611	219	47	62	96	171
5	Alperen Sengun A. Sengun	+410	2024-25	HOU	76	31.5	19.1	10.3	4.9	1.1	0.8	7.5	15.0	49.6	0.3	1.2	23.3	3.9	5.6	69.2	54.5	3.4	6.9	2.6	2,395	1,451	786	372	84	61	194	209
6	Luke Kornet L. Kornet	+401	2024-25	BOS	73	18.6	6.0	5.3	1.6	0.5	1.0	2.6	3.8	66.8	0.0	0.0	0.0	0.9	1.3	69.1	68.3	2.6	2.7	0.4	1,361	441	388	117	36	71	31	119
7	Al Horford A. Horford	+397	2024-25	BOS	60	27.6	9.0	6.2	2.1	0.6	0.9	3.3	7.7	42.3	1.9	5.2	36.3	0.6	0.6	89.5	56.3	1.3	4.8	0.8	1,658	538	369	128	36	51	46	81
8	Karl-Anthony Towns K. Towns	+378	2024-25	NYK	72	35.0	24.4	12.8	3.1	1.0	0.7	8.9	16.9	52.6	2.0	4.7	42.0	4.7	5.7	82.9	63.0	2.9	9.8	2.7	2,517	1,759	920	222	71	50	192	249
9	Naz Reid N. Reid	+342	2024-25	MIN	80	27.5	14.2	6.0	2.3	0.7	0.9	5.3	11.5	46.2	2.2	5.8	37.9	1.4	1.8	77.6	57.7	1.2	4.9	1.4	2,200	1,138	480	181	58	72	108	189
10	Jaren Jackson Jr. J. Jackson Jr.	+330	2024-25	MEM	74	29.8	22.2	5.6	2.0	1.2	1.5	8.0	16.4	48.8	2.0	5.3	37.5	4.2	5.4	78.1	59.1	1.2	4.4	2.1	2,207	1,641	417	148	92	113	153	257
11	Rudy Gobert R. Gobert	+327	2024-25	MIN	72	33.2	12.0	10.9	1.8	0.8	1.4	4.7	7.1	66.9	0.0	0.0		2.6	3.8	67.4	68.7	3.7	7.2	1.2	2,388	866	785	127	56	104	89	182
12	Chet Holmgren C. Holmgren	+294	2024-25	OKC	32	27.4	15.0	8.0	2.0	0.7	2.2	5.2	10.7	49.0	1.4	3.6	37.9	3.2	4.2	75.4	59.9	1.5	6.5	1.8	877	479	257	63	23	71	56	72
13	Myles Turner M. Turner	+202	2024-25	IND	72	30.2	15.6	6.5	1.5	0.8	2.0	5.4	11.3	48.1	2.2	5.5	39.6	2.6	3.3	77.3	61.2	1.3	5.3	1.7	2,174	1,120	471	111	54	144	123	183
14	Kristaps Porziņģis K. Porziņģis	+173	2024-25	BOS	42	28.8	19.5	6.8	2.1	0.7	1.5	6.6	13.7	48.3	2.5	6.0	41.2	3.8	4.7	80.9	61.8	1.6	5.1	1.3	1,210	818	284	87	31	63	53	116
15	Steven Adams S. Adams	+172	2024-25	HOU	58	13.7	3.9	5.6	1.1	0.4	0.5	1.6	2.9	54.5	0.0	0.0	0.0	0.7	1.6	46.2	54.1	2.9	2.8	0.9	794	225	327	66	22	28	54	60
16	Zach Edey Z. Edey	+164	2024-25	MEM	66	21.5	9.2	8.3	1.0	0.5	1.3	3.8	6.6	58.0	0.3	0.8	34.6	1.4	1.9	70.9	62.4	3.5	4.8	1.3	1,416	610	548	65	36	85	88	182
17	Neemias Queta N. Queta	+155	2024-25	BOS	62	13.9	5.0	3.8	0.7	0.3	0.7	2.1	3.3	65.0	0.0	0.0	0.0	0.7	1.0	75.4	67.4	1.4	2.4	0.6	863	310	236	45	18	42	40	106
18	Domantas Sabonis D. Sabonis	+145	2024-25	SAC	70	34.7	19.1	13.9	6.0	0.7	0.4	7.5	12.8	59.0	0.9	2.2	41.7	3.1	4.1	75.4	65.5	3.8	10.1	2.9	2,429	1,337	972	423	48	26	202	229
19	Brook Lopez B. Lopez	+134	2024-25	MIL	80	31.8	13.0	5.0	1.8	0.6	1.9	4.9	9.7	50.9	1.7	4.7	37.3	1.4	1.7	82.6	62.4	1.4	3.6	1.1	2,546	1,041	401	143	50	148	84	171
20	Dereck Lively II D. Lively II	+121	2024-25	DAL	36	23.1	8.7	7.5	2.4	0.6	1.6	3.7	5.3	70.2	0.0	0.0		1.3	2.0	63.0	70.4	2.9	4.6	1.1	833	314	270	85	20	56	41	100
21	Kevon Looney K. Looney	+119	2024-25	GSW	76	15.0	4.5	6.1	1.6	0.6	0.5	1.9	3.7	51.4	0.0	0.1	40.0	0.7	1.3	56.6	53.5	2.4	3.6	0.5	1,142	344	462	118	46	37	39	154
22	Victor Wembanyama V. Wembanyama	+102	2024-25	SAS	46	33.2	24.3	11.0	3.7	1.1	3.8	8.9	18.6	47.6	3.1	8.8	35.2	3.4	4.1	83.6	59.4	1.8	9.2	3.2	1,527	1,116	506	168	52	176	149	105
23	Jaxson Hayes J. Hayes	+87	2024-25	LAL	56	19.5	6.8	4.8	1.0	0.6	0.9	2.9	4.0	72.2	0.0	0.1	0.0	1.1	1.8	62.2	72.0	1.4	3.4	0.8	1,093	383	269	58	31	51	43	136
24	Goga Bitadze G. Bitadze	+80	2024-25	ORL	70	20.4	7.2	6.6	2.0	0.7	1.4	3.0	4.8	61.1	0.0	0.4	10.7	1.2	1.9	63.9	63.1	2.4	4.2	1.0	1,430	502	463	137	49	98	72	150
25	Day'Ron Sharpe D. Sharpe	+64	2024-25	BKN	50	18.1	7.9	6.6	1.8	0.8	0.8	3.3	6.3	52.1	0.2	0.9	24.4	1.1	1.5	75.7	56.8	3.0	3.6	1.3	907	397	330	91	41	42	63	113