I don't have anything for this season, but Shai Gilgeous-Alexander had the highest plus/minus in a 2025 playoff game, at +51 against the Nuggets on May 7.

Interpreted as:

highest +/- by a player in a game this playoffs

	NAME	+/-	DATE	TM		OPP	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Shai Gilgeous-Alexander S. Gilgeous-Alexander	+51	5/7/2025	OKC	vs	DEN	30	34	4	8	0	0	11	13	84.6	1	2	50.0	11	11	100.0	95.3	2	2	2	3
2	Jalen Williams J. Williams	+44	4/20/2025	OKC	vs	MEM	26	20	5	6	3	1	10	16	62.5	0	4	0.0	0	0		62.5	2	3	2	1
3	Jarrett Allen J. Allen	+42	4/28/2025	CLE	@	MIA	25	14	12	2	6	0	5	5	100.0	0	0		4	4	100.0	103.6	3	9	0	1
4	Alex Caruso A. Caruso	+40	5/18/2025	OKC	vs	DEN	26	11	0	3	3	0	5	7	71.4	1	3	33.3	0	0		78.6	0	0	0	3
5	Julius Randle J. Randle	+38	5/24/2025	MIN	vs	OKC	30	24	4	3	0	0	9	15	60.0	2	5	40.0	4	4	100.0	71.6	0	4	0	4
6	Cason Wallace C. Wallace	+38	5/18/2025	OKC	vs	DEN	29	7	3	5	2	0	3	10	30.0	1	6	16.7	0	0		35.0	1	2	1	1
7	Jarrett Allen J. Allen	+38	5/9/2025	CLE	@	IND	31	19	12	2	0	2	6	11	54.5	0	0		7	8	87.5	65.4	4	8	3	2
8	Anthony Edwards A. Edwards	+36	5/24/2025	MIN	vs	OKC	30	30	9	6	2	0	12	17	70.6	5	8	62.5	1	2	50.0	83.9	1	8	4	2
9	Jalen Williams J. Williams	+35	5/18/2025	OKC	vs	DEN	33	24	5	7	1	0	10	17	58.8	2	5	40.0	2	3	66.7	65.5	1	4	1	0
10	Donovan Mitchell D. Mitchell	+35	5/9/2025	CLE	@	IND	37	43	9	5	1	0	14	29	48.3	5	13	38.5	10	14	71.4	61.1	5	4	2	4
11	Isaiah Hartenstein I. Hartenstein	+35	4/20/2025	OKC	vs	MEM	21	14	8	5	1	0	7	8	87.5	0	0		0	0		87.5	4	4	0	1
12	Chet Holmgren C. Holmgren	+34	5/18/2025	OKC	vs	DEN	28	13	11	1	1	1	4	9	44.4	0	3	0.0	5	6	83.3	55.8	3	8	2	3
13	Luguentz Dort L. Dort	+34	5/7/2025	OKC	vs	DEN	27	12	1	0	1	1	4	13	30.8	2	9	22.2	2	2	100.0	43.2	0	1	0	3
14	Chet Holmgren C. Holmgren	+34	5/7/2025	OKC	vs	DEN	26	15	11	2	2	2	3	8	37.5	2	3	66.7	7	7	100.0	67.7	1	10	0	0
15	Jayson Tatum J. Tatum	+34	4/29/2025	BOS	vs	ORL	34	35	8	10	1	0	10	16	62.5	4	5	80.0	11	11	100.0	84.0	0	8	2	2
16	Michael Porter Jr. M. Porter Jr.	+34	4/29/2025	DEN	vs	LAC	37	14	2	1	0	1	5	10	50.0	3	5	60.0	1	1	100.0	67.0	0	2	0	4
17	Max Strus M. Strus	+34	4/28/2025	CLE	@	MIA	21	3	5	4	1	0	1	6	16.7	1	4	25.0	0	0		25.0	0	5	2	0
18	De'Andre Hunter D. Hunter	+34	4/26/2025	CLE	@	MIA	28	21	4	3	1	0	6	8	75.0	3	5	60.0	6	6	100.0	98.7	0	4	2	3
19	Ty Jerome T. Jerome	+33	4/26/2025	CLE	@	MIA	22	13	3	11	2	0	5	11	45.5	1	3	33.3	2	2	100.0	54.7	1	2	0	0
20	Shai Gilgeous-Alexander S. Gilgeous-Alexander	+32	5/18/2025	OKC	vs	DEN	36	35	3	4	3	1	12	19	63.2	3	4	75.0	8	9	88.9	76.2	0	3	0	2
21	Max Strus M. Strus	+32	5/9/2025	CLE	@	IND	33	20	7	7	0	1	8	12	66.7	4	8	50.0	0	0		83.3	2	5	0	5
22	Amen Thompson A. Thompson	+32	4/30/2025	HOU	vs	GSW	35	25	6	3	5	3	8	12	66.7	1	1	100.0	8	9	88.9	78.3	4	2	3	2
23	Michael Porter Jr. M. Porter Jr.	+31	5/3/2025	DEN	vs	LAC	30	15	6	0	0	0	6	11	54.5	3	8	37.5	0	0		68.2	0	6	0	2
24	Donovan Mitchell D. Mitchell	+31	4/28/2025	CLE	@	MIA	25	22	0	5	1	0	8	15	53.3	4	8	50.0	2	2	100.0	69.3	0	0	2	1
25	Sam Merrill S. Merrill	+31	4/28/2025	CLE	@	MIA	19	9	1	1	1	0	3	7	42.9	3	7	42.9	0	0		64.3	0	1	1	1